Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 7/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 5/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453000 | 0.85 | FGFR2 (0.52) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL17489704 | 0.85 | PDGFRA (0.65) | FGFR2PDGFRAPDGFRBKDR | |
| SCHEMBL4141203 | 0.84 | FGFR2 (0.60) | FGFR2PDGFRAPDGFRBKDR | |
| SCHEMBL12500026 | 0.82 | MET (0.52) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL4141201 | 0.82 | FGFR2 (0.59) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL10296329 | 0.81 | PDGFRB (0.55) | FGFR2PDGFRAPDGFRB | |
| SCHEMBL1893582 | 0.81 | PDGFRA (0.70) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL13955463 | 0.80 | PDGFRA (0.49) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL12500763 | 0.80 | MET (0.57) | FGFR2PDGFRAPDGFRBKDRMET | |
| SCHEMBL12501921 | 0.80 | AXL (0.62) | FGFR2PDGFRAPDGFRBKDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20110118470-A1 | NITROGEN-CONTAINING AROMATIC DERIVATIVES | FUNAHASHI YASUHIRO | 2011-05-19 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | FGFR2 969/4885PDGFRA 3131/4885PDGFRB 3824/4885 |
| US-20110118470-A1 | NITROGEN-CONTAINING AROMATIC DERIVATIVES | GNG2, GCG, FRG1 | FGFR2 1118/4885PDGFRA 3135/4885PDGFRB 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.