Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4126675 | 0.94 | SLC6A2 (0.55) | SLC6A2KCNH2SLC6A4SLC6A3HRH1 | |
| SCHEMBL4126668 | 0.94 | SLC6A2 (0.55) | SLC6A2KCNH2SLC6A4SLC6A3HRH1 | |
| SCHEMBL4131983 | 0.88 | SLC6A2 (0.54) | SLC6A2KCNH2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL4131990 | 0.88 | SLC6A2 (0.54) | SLC6A2KCNH2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL4132817 | 0.87 | SLC6A2 (0.57) | SLC6A2KCNH2SLC6A4SLC6A3HTR2C | |
| SCHEMBL4132811 | 0.87 | SLC6A2 (0.57) | SLC6A2KCNH2SLC6A4SLC6A3HTR2C | |
| SCHEMBL4145108 | 0.86 | CHRNB2 (0.51) | SLC6A2KCNH2SLC6A4SLC6A3HRH1 | |
| SCHEMBL4135565 | 0.86 | SLC6A2 (0.52) | SLC6A2KCNH2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL4127731 | 0.86 | SLC6A2 (0.52) | SLC6A2KCNH2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL4135569 | 0.86 | SLC6A2 (0.52) | SLC6A2KCNH2SLC6A4SLC6A3CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | PFIZER PRODUCTS INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | OPRL1, HTR5A, OPRD1 | SLC6A2 28/4885KCNH2 673/4885SLC6A4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.