Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.49 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430010 | 0.85 | GABRP (0.43) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| Hydrochloric Acid SCHEMBL5430002 | 0.84 | GABRP (0.42) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL13834197 | 0.83 | ALDH1A1 (0.54) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL4126615 | 0.77 | ALDH1A1 (0.43) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL12525332 | 0.77 | ALDH1A1 (0.50) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL3113139 | 0.73 | BAZ2B (0.54) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| Hydrochloric Acid SCHEMBL5546234 | 0.72 | BAZ2B (0.53) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL1298188 | 0.71 | BAZ2B (0.54) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL13346251 | 0.71 | BAZ2B (0.54) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL14267776 | 0.71 | BAZ2B (0.54) | ALDH1A1GAALMNABAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137554-A1 | 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | WYETH (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090131409-A1 | 1,4,5,6,7,8-HEXAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | WYETH (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137554-A1 | 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | NR5A2, NR1H2, NR2C2 | ALDH1A1 3508/4885GAA 4636/4885LMNA 3385/4885 |
| US-20090131409-A1 | 1,4,5,6,7,8-HEXAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | NR1H2, NR1H3, NR5A2 | ALDH1A1 3909/4885GAA 4784/4885LMNA 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.