Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134700 | 0.88 | NPC1 (0.38) | GAALMNAKDM4AMEN1KMT2A | |
| SCHEMBL4699942 | 0.78 | L3MBTL1 (0.45) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL4142173 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL23704882 | 0.74 | MDH1 (0.45) | KDM4A | |
| SCHEMBL13834197 | 0.74 | ALDH1A1 (0.54) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL630419 | 0.71 | IDO1 (0.47) | GAAKDM4AMEN1KMT2A | |
| SCHEMBL12525332 | 0.70 | ALDH1A1 (0.50) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL1004594 | 0.70 | BAZ2B (0.44) | ALDH1A1GAALMNABAZ2BBAZ2A | |
| SCHEMBL3699220 | 0.70 | SHBG (0.49) | ALDH1A1GAALMNAKDM4A | |
| SCHEMBL23705343 | 0.69 | TPMT (0.42) | ALDH1A1GAAKDM4AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137554-A1 | 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | WYETH (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090131409-A1 | 1,4,5,6,7,8-HEXAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | WYETH (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137554-A1 | 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | NR5A2, NR1H2, NR2C2 | ALDH1A1 3508/4885GAA 4636/4885LMNA 3385/4885 |
| US-20090131409-A1 | 1,4,5,6,7,8-HEXAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY | NR1H2, NR1H3, NR5A2 | ALDH1A1 3909/4885GAA 4784/4885LMNA 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.