SCHEMBL4143563

SCHEMBL4143563

Clc1cccc2c(C#Cc3ccccc3)c3ccccc3c(C#Cc3ccccc3)c12.c1ccc(-c2c3ccccc3c(-c3ccccc3)c3c(-c4ccccc4)c4ccccc4c(-c4ccccc4)c23)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.34
DYRK1A Q13627 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.33
ATM Q13315 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MAP2 P11137 1/20 0.33
ADK P55263 1/20 0.32
GRM4 Q14833 1/20 0.32
PTPRC P08575 1/20 0.30
PTPN2 P17706 1/20 0.30
PTPN1 P18031 1/20 0.30
PTPN6 P29350 1/20 0.30
PTPN9 P43378 1/20 0.30
DUSP3 P51452 1/20 0.30
PTPN11 Q06124 1/20 0.30
PTPN22 Q9Y2R2 1/20 0.30
CYP2A6 P11509 2/20 0.30
AKR1C2 P52895 1/20 0.30
AKR1C1 Q04828 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL432731 0.89 APP (0.43) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL20454318 0.89 APP (0.43) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL29365692 0.89 APP (0.43) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL427566 0.86 APP (0.46) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL30165319 0.85 APP (0.44) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL551446 0.85 APP (0.44) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL3623354 0.82 APP (0.36) APPL3MBTL1ATMTDP1GRM4
SCHEMBL15065239 0.80 GRM4 (0.36) APPDYRK1AL3MBTL1ATMTDP1
SCHEMBL30394466 0.79 APP (0.50) APPL3MBTL1ATMTDP1PTPRC
SCHEMBL2492685 0.79 APP (0.50) APPL3MBTL1ATMTDP1PTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8454991-B2 Method and device for photodynamic therapy QUEST PHARMATECH INC. 2013-06-04 US disclosed
US-20090204057-A1 METHOD AND DEVICE FOR PHOTODYNAMIC THERAPY QUEST PHARMATECH INC. (CA) 2009-08-13 US disclosed