Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.32 |
| ▸ | IGF1R | P08069 | 3/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.31 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.31 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463550 | 0.91 | DHODH (0.33) | DHODHIGF1RMRGPRX4MAOBCTSA | |
| SCHEMBL2459738 | 0.85 | MAOB (0.37) | DHODHIGF1RMRGPRX4MAOBHDAC4 | |
| SCHEMBL2463346 | 0.82 | IGF1R (0.35) | IGF1RMRGPRX4HDAC4JAK2JAK1 | |
| SCHEMBL2459920 | 0.82 | IGF1R (0.38) | IGF1RMRGPRX4MAOBHDAC4JAK2 | |
| SCHEMBL2460369 | 0.81 | IGF1R (0.38) | IGF1RMRGPRX4 | |
| SCHEMBL2459426 | 0.80 | BRD4 (0.36) | MRGPRX4MAOBHDAC4JAK2JAK1 | |
| SCHEMBL2460301 | 0.79 | IGF1R (0.35) | IGF1RMAOBJAK2JAK1 | |
| SCHEMBL2465897 | 0.79 | F9 (0.34) | IGF1RMRGPRX4MAOB | |
| SCHEMBL2460497 | 0.78 | JAK2 (0.40) | IGF1RMRGPRX4MAOBHDAC4JAK2 | |
| SCHEMBL2460207 | 0.78 | NR1H2 (0.35) | IGF1RMRGPRX4HDAC4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181940-A1 | Imidazopyrazine Tyrosine Kinase Inhibitors | OSI PHARMACEUTICALS, INC. | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181940-A1 | Imidazopyrazine Tyrosine Kinase Inhibitors | IGF1R, IRS1, IGFBP1 | DHODH 3525/4885IGF1R 1/4885MRGPRX4 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.