SCHEMBL4145121

SCHEMBL4145121

N#Cc1cc2c(cc1I)OCO2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.40
RAB9A P51151 4/20 0.40
HSD17B10 Q99714 6/20 0.38
NPSR1 Q6W5P4 4/20 0.38
KDM4E B2RXH2 3/20 0.38
ALDH1A1 P00352 3/20 0.38
HPGD P15428 3/20 0.38
RXFP1 Q9HBX9 3/20 0.38
GAA P10253 2/20 0.38
CASP1 P29466 1/20 0.38
CASP7 P55210 1/20 0.38
LMNA P02545 1/20 0.35
MAPT P10636 5/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
ALOX15 P16050 2/20 0.34
POLB P06746 1/20 0.34
ALOX12 P18054 1/20 0.34
ACACB O00763 1/20 0.34
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1742802 0.77 CYP3A4 (0.44) NPC1RAB9AHSD17B10ALDH1A1GAA
SCHEMBL31709528 0.77 CYP3A4 (0.44) NPC1RAB9AHSD17B10ALDH1A1GAA
SCHEMBL14172609 0.75 CYP3A4 (0.42) NPC1RAB9AHSD17B10NPSR1KDM4E
SCHEMBL3739271 0.75 ALDH1A1 (0.40) NPC1RAB9AHSD17B10NPSR1KDM4E
SCHEMBL10979117 0.75 MAPT (0.47) NPC1RAB9AHSD17B10NPSR1KDM4E
SCHEMBL1622661 0.75 MAPT (0.43) NPC1RAB9AHSD17B10NPSR1KDM4E
SCHEMBL21763267 0.74 TTR (0.42) TSHR
SCHEMBL24517017 0.73 PRKCI (0.34) NPC1RAB9AHSD17B10NPSR1KDM4E
SCHEMBL29618388 0.73 PRKCI (0.34) NPC1RAB9AHSD17B10NPSR1KDM4E
SCHEMBL11697944 0.72 MAPT (0.57) KDM4EALDH1A1HPGDGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192687-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2023-06-22 US disclosed
US-11560377-B2 Fused amino pyridine as HSP90 inhibitors Guris, Inc. (US) 2023-01-24 US disclosed
US-20210292317-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2021-09-23 US disclosed
US-10844056-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2020-11-24 US disclosed
US-20200062754-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2020-02-27 US disclosed
US-10428068-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2019-10-01 US disclosed
US-20190010152-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2019-01-10 US disclosed
US-10035797-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2018-07-31 US disclosed
US-20170267674-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2017-09-21 US disclosed
US-9630965-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2017-04-25 US disclosed
US-20160058742-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2016-03-03 US disclosed
US-9040556-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2015-05-26 US disclosed
US-20140221343-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS, INC. (US) 2014-08-07 US disclosed
US-8586605-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2013-11-19 US disclosed
EP-2069324-B1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS INC (US) 2013-07-31 EP disclosed
US-8324240-B2 Fused amino pyridine as HSP90 inhibitors CURIS, INC. (US) 2012-12-04 US disclosed
US-20120237508-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS, INC. 2012-09-20 US disclosed
EP-2069324-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS Curis, Inc. (US) 2009-06-17 EP disclosed
WO-2008115719-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS, INC. (US) 2008-09-25 WO disclosed
US-20080234314-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS CURIS, INC. 2008-09-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190010152-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-10428068-B2 Fused amino pyridine as HSP90 inhibitors HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20170267674-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20160058742-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20120237508-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20230192687-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20080234314-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20210292317-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20200062754-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-20140221343-A1 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-11560377-B2 Fused amino pyridine as HSP90 inhibitors HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-10844056-B2 Fused amino pyridine as HSP90 inhibitors HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885
US-10035797-B2 Fused amino pyridine as HSP90 inhibitors HSP90B1, HSP90AB1, HSP90AB2P NPC1 3367/4885RAB9A 1177/4885HSD17B10 2955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.