Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | TDO2 | P48775 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL2391505 | 0.91 | IDO1 (0.47) | IDO1TDO2GAASLC6A2SLC6A4 | |
| SCHEMBL2066940 | 0.84 | IDO1 (0.45) | IDO1TDO2GAAOPRM1OPRD1 | |
| SCHEMBL31409208 | 0.82 | IDO1 (0.43) | IDO1TDO2GAASLC6A2SLC6A4 | |
| SCHEMBL7909645 | 0.82 | GAA (0.55) | IDO1TDO2GAASLC6A2SLC6A4 | |
| SCHEMBL24550469 | 0.81 | SLC6A2 (0.50) | IDO1TDO2GAASLC6A2SLC6A4 | |
| SCHEMBL9480974 | 0.78 | IDO1 (0.52) | IDO1TDO2GAAOPRM1OPRD1 | |
| SCHEMBL3782815 | 0.78 | IDO1 (0.52) | IDO1TDO2GAAOPRM1OPRD1 | |
| SCHEMBL2391501 | 0.78 | SLC2A1 (0.46) | IDO1TDO2GAAALDH1A1KMT2A | |
| SCHEMBL17071859 | 0.76 | IDO1 (0.50) | IDO1TDO2GAAOPRM1OPRD1 | |
| SCHEMBL8108090 | 0.76 | IDO1 (0.50) | IDO1TDO2GAAOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130281504-A1 | Reduction of Microglia-Mediated Neurotoxicity by KCa3.1 Inhibition | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-24 | — | — | US | disclosed |
| WO-2012006117-A2 | REDUCTION OF MICROGLIA-MEDIATED NEUROTOXICITY BY KCA3.1 INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-01-12 | — | — | WO | disclosed |
| US-7531573-B2 | potent, selective and safe inhibitors of the Ca2+-activated potassium channel | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531573-B2 | potent, selective and safe inhibitors of the Ca2+-activated potassium channel | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |