Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olsalazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | BLVRB | P30043 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PHLPP2 | Q6ZVD8 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxaceprol SCHEMBL5207289 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL3799956 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL25978 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL4252591 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL25976 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL3780150 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL25977 | 0.75 | ATM (1.00) | ATMALDH1A1 | |
| Oxaceprol SCHEMBL11772248 | 0.73 | ATM (0.96) | ATMALDH1A1 | |
| Olsalazine SCHEMBL29385751 | 0.73 | MEN1 (1.00) | MEN1KMT2ABLVRBPDE4AKDR | |
| Olsalazine SCHEMBL29861404 | 0.73 | MEN1 (1.00) | MEN1KMT2ABLVRBPDE4AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170368185-A9 | METHOD OF PREPARING DENDRITIC DRUGS | CHAI MINGHUI (CN) | 2017-12-28 | — | — | US | claimed |
| US-20160206746-A1 | METHOD OF PREPARING DENDRITIC DRUGS | CHAI MINGHUI (CN) | 2016-07-21 | — | — | US | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| US-20070190151-A1 | Method of preparing dendritic drugs | CENTRAL MICHIGAN UNIVERSITY BOARD OF TRUSTEES | 2007-08-16 | — | — | US | claimed |
| WO-2007087256-A2 | METHOD OF PREPARING DENDRITIC DRUGS | CENTRAL MICHIGAN UNIVERSITY BOARD OF TRUSTEES (US) | 2007-08-02 | — | — | WO | claimed |
| EP-1734936-A2 | AMPHIPHILIC STAR-LIKE OR SCOPRION-LIKE MACROMOLECULES, VARIOUS COMPOSITIONS AND USES THEREOF | Rutgers, The State University (US) | 2006-12-27 | — | — | EP | claimed |
| EP-1706148-A2 | LIPID-BASED DISPERSIONS USEFUL FOR DRUG DELIVERY | GILEAD SCIENCES, INC. (US) | 2006-10-04 | — | — | EP | claimed |
| WO-2005074887-A2 | AMPHIPHILIC STAR-LIKE OR SCORPION-LIKE MACROMOLECULES, VARIOUS COMPOSITIONS AND USES THEREOF | RUTGERS, THE STATE UNIVERSITY (US) | 2005-08-18 | — | — | WO | claimed |
| WO-2005070465-A2 | LIPID-BASED DISPERSIONS USEFUL FOR DRUG DELIVERY | GILEAD SCIENCES, INC. (US) | 2005-08-04 | — | — | WO | claimed |
| US-20170368185-A9 | METHOD OF PREPARING DENDRITIC DRUGS | CHAI MINGHUI (CN) | 2017-12-28 | — | — | US | disclosed |
| US-9603941-B2 | Method of preparing dendritic drugs | CENTRAL MICHIGAN UNIVERSITY BOARD OF TRUSTEES | 2017-03-28 | — | — | US | disclosed |
| US-20160206746-A1 | METHOD OF PREPARING DENDRITIC DRUGS | CHAI MINGHUI (CN) | 2016-07-21 | — | — | US | disclosed |
| WO-2014176460-A1 | METHODS OF TREATING BEHAVIORIAL AND/OR MENTAL DISORDERS | CHAU DAVID T (US) | 2014-10-30 | — | — | WO | disclosed |
| EP-1734936-B1 | AMPHIPHILIC STAR-LIKE OR SCOPRION-LIKE MACROMOLECULES, VARIOUS COMPOSITIONS AND USES THEREOF | UNIV RUTGERS (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2003072020-A2 | THERAPEUTICAL POLYANHYDRIDE COMPOUNDS FOR DRUG DELIVERY | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2003-09-04 | — | — | WO | disclosed |
| US-6613807-B2 | Linking low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol, which is released when hydrolysis occurs | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2003-09-02 | — | — | US | disclosed |
| WO-2003048190-A2 | ACYCLOVIR-PEPTIDE ANALOGS | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2003-06-12 | — | — | WO | disclosed |
| EP-1307233-A2 | THERAPEUTIC POLYANHYDRIDE COMPOUNDS FOR DRUG DELIVERY | Rutgers, The State University (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020098161-A1 | Therapeutic polyanhydride compounds for drug delivery | POLYMERIX CORPORATION | 2002-07-25 | — | — | US | disclosed |
| WO-2002009767-A2 | THERAPEUTIC POLYANHYDRIDE COMPOUNDS FOR DRUG DELIVERY | RUTGERS, THE STATE UNIVERSITY (US) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070190151-A1 | Method of preparing dendritic drugs | MYD88, TLR3, TLR6 | PTGS1 1371/4885PTGS2 1564/4885ATM 3175/4885 |
| US-20020098161-A1 | Therapeutic polyanhydride compounds for drug delivery | SLC43A1, CD44, DHFR | PTGS1 177/4885PTGS2 246/4885ATM 4107/4885 |
| US-20160206746-A1 | METHOD OF PREPARING DENDRITIC DRUGS | MYD88, TLR3, TLR6 | PTGS1 1371/4885PTGS2 1564/4885ATM 3175/4885 |
| US-20170368185-A9 | METHOD OF PREPARING DENDRITIC DRUGS | MYD88, TLR3, TLR6 | PTGS1 1371/4885PTGS2 1564/4885ATM 3175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.