Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.61 |
| ▸ | RXRG | P48443 | 13/20 | 0.61 |
| ▸ | RXRB | P28702 | 12/20 | 0.61 |
| ▸ | RARB | P10826 | 8/20 | 0.61 |
| ▸ | RARG | P13631 | 8/20 | 0.61 |
| ▸ | RARA | P10276 | 6/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4146810 | 1.00 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL14020532 | 1.00 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL7178687 | 0.90 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6915914 | 0.90 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6915920 | 0.90 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6915917 | 0.90 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6915924 | 0.90 | RXRA (0.61) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6916842 | 0.80 | RXRA (0.49) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL7735872 | 0.79 | RXRA (0.52) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL7735871 | 0.79 | RXRA (0.52) | RXRARXRGRXRBRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090016991-A1 | Rxr Antagonist Treatment Against Multiple Sclerosis | BOLLAG WERNER | 2009-01-15 | — | — | US | claimed |
| US-20080242729-A1 | Rxr Antagonists in the Treatment of Inflammatory Diseases | BOLLAG WERNER | 2008-10-02 | — | — | US | claimed |
| EP-1771166-A2 | RXR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY DISEASES | Bollag, Werner (CH) | 2007-04-11 | — | — | EP | claimed |
| EP-1771163-A1 | RXR ANTAGONIST TREATMENT AGAINST MULTIPLE SCLEROSIS | Bollag, Werner (CH) | 2007-04-11 | — | — | EP | claimed |
| WO-2006010504-A1 | RXR ANTAGONIST TREATMENT AGAINST MULTIPLE SCLEROSIS | BOLLAG WERNER (CH) | 2006-02-02 | — | — | WO | claimed |
| WO-2006010503-A2 | RXR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY DISEASES | BOLLAG WERNER (CH) | 2006-02-02 | — | — | WO | claimed |
| EP-1621191-A1 | Treatment of inflammatory diseases by RXR Antagonists | Bollag, Werner (CH) | 2006-02-01 | — | — | EP | claimed |
| US-20080255206-A1 | Rxr Agonists and Antagonists, Alone or in Combination with Ppar Ligands, in the Treatment of Metabolic and Cardiovascular Diseases | BOLLAG WERNER | 2008-10-16 | — | — | US | disclosed |
| US-20080242729-A1 | Rxr Antagonists in the Treatment of Inflammatory Diseases | BOLLAG WERNER | 2008-10-02 | — | — | US | disclosed |
| EP-1621191-A1 | Treatment of inflammatory diseases by RXR Antagonists | Bollag, Werner (CH) | 2006-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090016991-A1 | Rxr Antagonist Treatment Against Multiple Sclerosis | RXRA, RXRB, RXRG | RXRA 1/4885RXRG 3/4885RXRB 2/4885 |
| US-20080242729-A1 | Rxr Antagonists in the Treatment of Inflammatory Diseases | RXRA, RXRB, RXRG | RXRA 1/4885RXRG 3/4885RXRB 2/4885 |
| US-20080255206-A1 | Rxr Agonists and Antagonists, Alone or in Combination with Ppar Ligands, in the Treatment of Metabolic and Cardiovascular Diseases | RXRA, RXRG, RXRB | RXRA 1/4885RXRG 2/4885RXRB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.