Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4164839 | 0.85 | KDM4E (0.35) | KDM4EADRA2BMAPK1SMN1; SMN2CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL4146945 | 0.85 | KDM4E (0.39) | KDM4EADRA2BMAPK1SMN1; SMN2CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL4183630 | 0.84 | KDM4E (0.34) | KDM4EADRA2BMAPK1CYP1A2ALDH1A1 | |
| SCHEMBL4175956 | 0.81 | KDM4E (0.37) | KDM4EADRA2BMAPK1SMN1; SMN2CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL4175924 | 0.78 | KDM4E (0.42) | KDM4ESMN1; SMN2CYP1A2ALDH1A1HPGD | |
| Trifluoroacetic Acid SCHEMBL4172149 | 0.77 | KDM4E (0.35) | KDM4EADRA2BMAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL3975810 | 0.77 | MTNR1A (0.41) | KDM4ESMN1; SMN2CYP1A2ALDH1A1MTNR1A | |
| Trifluoroacetic Acid SCHEMBL4125561 | 0.75 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2ALDH1A1HPGD | |
| Trifluoroacetic Acid SCHEMBL4125556 | 0.75 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2ALDH1A1HPGD | |
| Trifluoroacetic Acid SCHEMBL5264108 | 0.75 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP1A2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569550-B2 | 14 and 15 membered ring compounds | GLAXO GROUP LIMITED (GB) | 2009-08-04 | — | — | US | disclosed |
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20070293472-A1 | Novel 14 and 15 Membered Ring Compounds | GLAXO GROUP LIMITED (GB) | 2007-12-20 | — | — | US | disclosed |
| US-20070185117-A1 | Novel 14 and 15 membrered ring compounds | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185117-A1 | Novel 14 and 15 membrered ring compounds | CYP51A1, LSS, IL17A | KDM4E 3840/4885ADRA2B 3996/4885MAPK1 2826/4885 |
| US-20070293472-A1 | Novel 14 and 15 Membered Ring Compounds | IL17A, CYP51A1, IL15 | KDM4E 3390/4885ADRA2B 4568/4885MAPK1 3757/4885 |
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885ADRA2B 2901/4885MAPK1 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.