Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158014 | 0.88 | IGF1R (0.39) | IGF1RFGFR1KDR | |
| SCHEMBL4557094 | 0.85 | IGF1R (0.36) | IGF1RFGFR1KDR | |
| SCHEMBL4160491 | 0.83 | IGF1R (0.41) | IGF1RFGFR1KDR | |
| SCHEMBL3942011 | 0.75 | IGF1R (0.40) | IGF1RFGFR1KDR | |
| SCHEMBL4159933 | 0.75 | IGF1R (0.39) | IGF1RFGFR1KDR | |
| SCHEMBL4161747 | 0.73 | NTRK1 (0.35) | IGF1RFGFR1KDR | |
| SCHEMBL5096819 | 0.72 | IGF1R (0.49) | IGF1RFGFR1KDR | |
| SCHEMBL4167900 | 0.72 | IGF1R (0.46) | IGF1RFGFR1KDR | |
| SCHEMBL5103415 | 0.72 | IGF1R (0.62) | IGF1RFGFR1KDR | |
| SCHEMBL4169882 | 0.71 | HTR7 (0.39) | IGF1RFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |