Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | PAK3 | O75914 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159418 | 0.90 | IGF1R (0.37) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4159559 | 0.87 | IGF1R (0.36) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4159933 | 0.86 | IGF1R (0.39) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4169882 | 0.85 | HTR7 (0.39) | IGF1RFGFR1KDRNTRK1IDH1 | |
| SCHEMBL4158014 | 0.84 | IGF1R (0.39) | IGF1RFGFR1KDRNTRK1IDH1 | |
| SCHEMBL4160491 | 0.83 | IGF1R (0.41) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4161747 | 0.82 | NTRK1 (0.35) | IGF1RFGFR1KDRNTRK1IDH1 | |
| SCHEMBL3980913 | 0.77 | FGFR1 (0.50) | IGF1RFGFR1KDRINSRFGFR3 | |
| SCHEMBL4162734 | 0.76 | HTR7 (0.41) | NTRK1IDH1JAK2JAK3 | |
| SCHEMBL3985659 | 0.76 | JAK2 (0.51) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |