Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147235 | 0.83 | IGF1R (0.36) | IGF1RKDRFGFR1 | |
| SCHEMBL4167900 | 0.83 | IGF1R (0.46) | IGF1RKDRFGFR1INSRNTRK1 | |
| SCHEMBL4159933 | 0.78 | IGF1R (0.39) | IGF1RKDRFGFR1INSRNTRK1 | |
| SCHEMBL3983403 | 0.77 | IGF1R (0.67) | IGF1RKDRFGFR1EGFRINSR | |
| SCHEMBL3985659 | 0.77 | JAK2 (0.51) | IGF1RKDRFGFR1EGFRINSR | |
| SCHEMBL4094616 | 0.77 | JAK2 (0.51) | IGF1RKDRFGFR1EGFRINSR | |
| SCHEMBL4159559 | 0.77 | IGF1R (0.36) | IGF1RKDRFGFR1EGFRINSR | |
| SCHEMBL3934716 | 0.76 | NR3C2 (0.44) | IGF1RKDRFGFR1EGFRNTRK1 | |
| SCHEMBL4169882 | 0.76 | HTR7 (0.39) | IGF1RKDRFGFR1NTRK1 | |
| SCHEMBL3950749 | 0.75 | IGF1R (0.67) | IGF1RKDRFGFR1EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |