SCHEMBL414795

SCHEMBL414795

NS(=O)(=O)c1cccc([N+](=O)[O-])c1[N+](=O)[O-]

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 2/20 0.56
KMT2A Q03164 4/20 0.53
MEN1 O00255 2/20 0.53
TSHR P16473 1/20 0.52
CA2 P00918 5/20 0.49
CA9 Q16790 3/20 0.49
F2 P00734 2/20 0.46
PRSS1 P07477 2/20 0.46
PRSS2 P07478 2/20 0.46
PRSS3 P35030 2/20 0.46
CA1 P00915 3/20 0.46
MMP1 P03956 1/20 0.46
MMP2 P08253 1/20 0.46
MMP9 P14780 1/20 0.46
MMP8 P22894 1/20 0.46
MMP13 P45452 1/20 0.46
TDP1 Q9NUW8 3/20 0.46
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
HPGD P15428 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31294149 0.85 KMT2A (0.53) GPR35KMT2AMEN1TSHRCA2
SCHEMBL3193995 0.85 KMT2A (0.68) GPR35KMT2AMEN1TSHRCA2
SCHEMBL27412106 0.83 CA2 (0.44) GPR35KMT2AMEN1TSHRCA2
SCHEMBL4158554 0.82 KMT2A (0.70) KMT2AMEN1CA2CA9F2
SCHEMBL370668 0.82 KMT2A (0.70) KMT2AMEN1CA2CA9F2
SCHEMBL8565033 0.81 KMT2A (0.53) GPR35KMT2AMEN1TSHRCA2
SCHEMBL31294204 0.81 KMT2A (0.53) GPR35KMT2AMEN1TSHRCA2
SCHEMBL31294234 0.81 KMT2A (0.53) GPR35KMT2AMEN1TSHRCA2
SCHEMBL7531981 0.81 CA2 (0.59) GPR35KMT2AMEN1CA2CA9
SCHEMBL7531976 0.81 KMT2A (0.53) GPR35KMT2AMEN1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119798210-B Preparation method of high-purity glycolide 山东金特安全科技有限公司 2025-05-20 CN claimed
CN-119798210-A Preparation method of high-purity glycolide 山东金特安全科技有限公司 2025-04-11 CN claimed
CN-108586735-A A kind of releasable SO2Polymer, preparation method and its application and nano-micelle 中国科学院长春应用化学研究所 2018-09-28 CN claimed
WO-2013102936-A1 N-(3-((DIETHYLAMINO) METHYL)-4-HYDROXYPHENYL)-N-(QUINOLIN-4-YL) SULFONAMIDES FOR THE TREATMENT OF TUBERCULOSIS AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2013-07-11 WO claimed
US-20260138946-A1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB CURIA SPAIN S A U (ES) 2026-05-21 US disclosed
US-12552746-B2 Process and intermediates for the preparation of upadacitinib CURIA SPAIN, S.A.U. (ES) 2026-02-17 US disclosed
US-12543674-B2 Embryogenesis factors for cellular reprogramming of a plant cell PIONEER HI-BRED INTERNATIONAL, INC. (US) 2026-02-10 US disclosed
US-20250277230-A1 PARTHENOGENESIS METHODS AND COMPOSITIONS PIONEER HI-BRED INTERNATONAL, INC. (US) 2025-09-04 US disclosed
CN-119798210-B Preparation method of high-purity glycolide 山东金特安全科技有限公司 2025-05-20 CN disclosed
CN-115151529-B Processes and intermediates for preparing Wu Pati n 库里亚西班牙公司 2025-04-22 CN disclosed
CN-119798210-A Preparation method of high-purity glycolide 山东金特安全科技有限公司 2025-04-11 CN disclosed
US-20250115924-A1 SYSTEMS AND METHODS FOR CELLULAR REPROGRAMMING OF A PLANT CELL PIONEER HI-BRED INTERNATIONAL, INC. (US) 2025-04-10 US disclosed
EP-1216227-A2 PREPARATION OF SULFONYL IMINE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2002-06-26 EP disclosed
US-6380429-B1 OXIDATION OF SULFONAMIDE E. I. DU PONT NEMOURS AND COMPANY 2002-04-30 US disclosed
WO-2001023352-A2 PREPARATION OF SULFONYL IMINE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-04-05 WO disclosed
EP-0949238-A1 SUBSTITUTED PROPIONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-10-13 EP disclosed
EP-0616609-A1 NITROANILINE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS. CANCER RES CAMPAIGN TECH (GB) 1994-09-28 EP disclosed
CN-1047220-A PAN GRANULATION DU PONT (US) 1990-11-28 CN disclosed
US-4897423-A Dinitrobenzenesulfonamides MERCK & CO. INC. (US) 1990-01-30 US disclosed
EP-0037030-A1 Aromatic diamines containing sulphon amide groups BAYER AG (DE) 1981-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260138946-A1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB JAK1, JAK3, JAK2 GPR35 4678/4885KMT2A 679/4885MEN1 348/4885
US-12552746-B2 Process and intermediates for the preparation of upadacitinib JAK1, JAK3, MET GPR35 4728/4885KMT2A 686/4885MEN1 260/4885
US-12543674-B2 Embryogenesis factors for cellular reprogramming of a plant cell CCNB2, CCNB1, CCNB3 GPR35 4200/4885KMT2A 2450/4885MEN1 2864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.