Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 5/20 | 0.39 |
| ▸ | TDO2 | P48775 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 2/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4152220 | 0.88 | PRKCI (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL4148716 | 0.80 | MEN1 (0.46) | KCNH2MAPK1 | |
| SCHEMBL4159891 | 0.78 | SYK (0.46) | CHRNB2CHRNA4CHEK1PRKCZSYK | |
| SCHEMBL14409567 | 0.72 | PRKCI (0.51) | CHRNB4CHRNA3IDO1TDO2PRKCI | |
| SCHEMBL14416943 | 0.72 | PRKCI (0.51) | CHRNB4CHRNA3IDO1TDO2PRKCI | |
| SCHEMBL14416942 | 0.72 | PRKCI (0.51) | CHRNB4CHRNA3IDO1TDO2PRKCI | |
| SCHEMBL14603115 | 0.72 | CHRNB2 (0.49) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL4654443 | 0.72 | LTA4H (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL1751545 | 0.72 | LTA4H (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL1298841 | 0.70 | CYP19A1 (0.39) | CHRNB4CHRNA3IDO1TDO2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | CHRNB4 1231/4885CHRNA3 1480/4885CHRNB2 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.