Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 4/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 5/20 | 0.36 |
| ▸ | HAT1 | O14929 | 4/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757131 | 1.00 | CTSS (0.47) | CTSSCTSKTP53CTSBCTSL | |
| SCHEMBL3684493 | 0.89 | TP53 (0.44) | CTSSCTSKTP53CTSB | |
| SCHEMBL4140566 | 0.89 | TP53 (0.44) | CTSSCTSKTP53CTSB | |
| SCHEMBL3646400 | 0.87 | CTSK (0.46) | CTSSCTSKTP53CTSBPRSS1 | |
| SCHEMBL3646394 | 0.87 | CTSK (0.46) | CTSSCTSKTP53CTSBPRSS1 | |
| SCHEMBL3646395 | 0.87 | CTSK (0.46) | CTSSCTSKTP53CTSBPRSS1 | |
| SCHEMBL3644459 | 0.84 | CTSK (0.40) | CTSSCTSKTP53 | |
| SCHEMBL3804920 | 0.84 | CTSK (0.40) | CTSSCTSKTP53 | |
| SCHEMBL3804922 | 0.84 | CTSK (0.40) | CTSSCTSKTP53 | |
| SCHEMBL264421 | 0.83 | CYP3A4 (0.44) | CTSSCTSKTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036422-A1 | MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036422-A1 | MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, MTNR1A | CTSS 4504/4885CTSK 4783/4885TP53 4876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.