Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001953 | 0.88 | TSHR (0.72) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL4004295 | 0.85 | TSHR (0.52) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL31684034 | 0.83 | TSHR (0.78) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL4555453 | 0.83 | TSHR (0.78) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL28765963 | 0.82 | TSHR (0.49) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL27974780 | 0.82 | CHRM4 (0.54) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL4001721 | 0.81 | KMT2A (0.52) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL10723724 | 0.81 | CHRM4 (0.64) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL4790629 | 0.77 | ALDH1A1 (0.57) | TSHRCYP2C9ALDH1A1KDM4EPOLB | |
| SCHEMBL3244492 | 0.75 | CYP3A4 (0.74) | TSHRCYP3A4CYP2C9CYP2C19MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |