Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 10/20 | 0.58 |
| ▸ | CDK1 | P06493 | 7/20 | 0.53 |
| ▸ | CDK9 | P50750 | 6/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 5/20 | 0.53 |
| ▸ | CCNH | P51946 | 5/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.53 |
| ▸ | CHUK | O15111 | 8/20 | 0.52 |
| ▸ | IKBKG | Q9Y6K9 | 8/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4151110 | 0.87 | IKBKB (0.64) | IKBKBCDK1CDK9CDK2CCNT1 | |
| SCHEMBL3521365 | 0.82 | GSK3B (0.57) | IKBKBCDK1CDK9CDK2CCNT1 | |
| SCHEMBL3516178 | 0.76 | IKBKB (0.69) | IKBKBCDK1CDK2CHUKIKBKG | |
| SCHEMBL4155684 | 0.69 | IKBKB (0.59) | IKBKBCDK1CDK9CDK2CCNT1 | |
| SCHEMBL4160812 | 0.69 | CDK2 (0.64) | CDK1CDK9CDK2CCNT1CCNB1 | |
| SCHEMBL4168095 | 0.69 | CDK2 (0.78) | CDK1CDK9CDK2CCNT1CCNB1 | |
| SCHEMBL4167257 | 0.69 | CDK2 (0.64) | IKBKBCDK1CDK9CDK2CCNT1 | |
| SCHEMBL4146248 | 0.69 | IKBKB (0.56) | IKBKBCDK1CDK9CDK2CCNT1 | |
| SCHEMBL8308064 | 0.68 | IKBKB (0.82) | IKBKBCDK2CHUKIKBKGAURKA | |
| SCHEMBL3521539 | 0.68 | IKBKB (0.76) | IKBKBCDK1CDK9CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | claimed |
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT1, CTNNB1, WNT3A | IKBKB 1593/4885CDK1 493/4885CDK9 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.