Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.90 |
| ▸ | TP53 | P04637 | 1/20 | 0.90 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.90 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.90 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8657252 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL29068820 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6466124 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL41492 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL6466120 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL41493 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL41494 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6466117 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL716254 | 1.00 | — | — | |
| Maleic Acid SCHEMBL716253 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519449-B1 | METHODS OF PREPARING A CATALYST | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2026-04-08 | — | — | EP | claimed |
| EP-4065236-B1 | METHOD FOR THE DECOLORIZATION OF KERATIN MATERIAL THAT HAS BEEN DYED USING A PIGMENT | HENKEL AG & CO KGAA (DE) | 2025-06-11 | — | — | EP | claimed |
| WO-2025097045-A1 | COLLOIDAL FOOD BASE COMPOSITIONS COMPRISING MYCELIAL BIOMASS | THE FYNDER GROUP, INC (US) | 2025-05-08 | — | — | WO | claimed |
| CN-116143129-B | Preparation method and application of peanut-shaped ultra-high-purity silica sol | 万华化学集团股份有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119570870-A | Method for synthesizing L-2-aminobutyric acid and L-2-aminobutanamide hydrochloride and application | 浙江永太科技股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| EP-3083040-B1 | HIGH-CONCENTRATION SILVER SOLUTIONS FOR ETHYLENE OXIDE CATALYST PREPARATION | SCIENT DESIGN LLC (US) | 2025-03-05 | — | — | EP | claimed |
| CN-119194450-A | Copper-titanium structure etching composition and preparation method thereof | 四川和晟达电子科技有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-118360606-A | Hydrogen peroxide metal etching solution composition and use method thereof | 四川和晟达电子科技有限公司 | 2024-07-19 | — | — | CN | claimed |
| EP-4372013-A2 | METHODS OF PREPARING A CATALYST | Chevron Phillips Chemical Company LP (US) | 2024-05-22 | — | — | EP | claimed |
| CN-117866866-A | Recombinant escherichia coli for producing exendin by utilizing fumaric acid as well as construction method and application thereof | 浙江绿创生物科技有限公司 | 2024-04-12 | — | — | CN | claimed |
| EP-0125105-A2 | Immobilization of catalytically active microorganisms in agar gel fibers | PFIZER INC. (US) | 1984-11-14 | — | — | EP | claimed |
| EP-0123903-A2 | Method for producing L-aspartic acid | Tanabe Seiyaku Co., Ltd. (JP) | 1984-11-07 | — | — | EP | claimed |
| US-4456685-A | USING P,P*-DICYANATODIPHENYLMETHANE AND DIMERS AND TRIMERS | W. R. GRACE & CO. (US) | 1984-06-26 | — | — | US | claimed |
| EP-0110422-A2 | Process for producing L-aspartic acid | Tanabe Seiyaku Co., Ltd. (JP) | 1984-06-13 | — | — | EP | claimed |
| US-4436813-A | HAVING L-ASPARTASE ACTIVITY, FROM AMMONIUM FUMARATE | PURIFICATION ENGINEERING, INC. (US) | 1984-03-13 | — | — | US | claimed |
| US-4434228-A | WITH POILYCARBOXYLIC ACID | GENEX CORPORATION (US) | 1984-02-28 | — | — | US | claimed |
| EP-0089165-A2 | Immobilized microbial cells and process for preparing and using same | RHONE-POULENC CHIMIE (FR) | 1983-09-21 | — | — | EP | claimed |
| EP-0032987-A1 | Thermophilic aspartase, processes for producing, culture used, and L-aspartic acid preparation process using the same | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-08-05 | — | — | EP | claimed |
| US-4232046-A | Liquid starch-urea ruminant feed and method of preparing same | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1980-11-04 | — | — | US | claimed |
| US-3988483-A | Liquid starch-urea ruminant feed and method of producing same | THE KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1976-10-26 | — | — | US | claimed |