Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.90 |
| ▸ | TP53 | P04637 | 1/20 | 0.90 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.90 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.90 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8657252 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL41491 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL29068820 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6466124 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL41492 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL6466120 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL41493 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL41494 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6466117 | 1.00 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL716254 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1424 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026101451-A1 | SUPERPARAMAGNETIC MICROSPHERES AND METHOD FOR THE PRODUCTION THEREOF | N-LAB TECHNOLOGY CENTER PTE. LTD. (SG) | 2026-05-15 | — | — | WO | claimed |
| EP-4065236-B1 | METHOD FOR THE DECOLORIZATION OF KERATIN MATERIAL THAT HAS BEEN DYED USING A PIGMENT | HENKEL AG & CO KGAA (DE) | 2025-06-11 | — | — | EP | claimed |
| CN-116514091-B | Preparation method and application of lithium iron phosphate | 河南佰利新能源材料有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119858232-A | Device and method for processing ceramic wet blank by ultrasonic vibration | 中国科学院上海硅酸盐研究所 | 2025-04-22 | — | — | CN | claimed |
| CN-119866366-A | Dispersing agent and aqueous coating composition | 圣诺普科有限公司 | 2025-04-22 | — | — | CN | claimed |
| CN-119816561-A | Recyclable polymer aerogel, cold accumulation phase change composite material, preparation method and application | 中国石油化工股份有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-116143129-B | Preparation method and application of peanut-shaped ultra-high-purity silica sol | 万华化学集团股份有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119570870-A | Method for synthesizing L-2-aminobutyric acid and L-2-aminobutanamide hydrochloride and application | 浙江永太科技股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| EP-3083040-B1 | HIGH-CONCENTRATION SILVER SOLUTIONS FOR ETHYLENE OXIDE CATALYST PREPARATION | SCIENT DESIGN LLC (US) | 2025-03-05 | — | — | EP | claimed |
| US-12227623-B2 | Water-absorbing hydrogel and method for producing the same | NISSAN CHEMICAL CORPORATION (JP) | 2025-02-18 | — | — | US | claimed |
| EP-0683231-A1 | Process for production of L-aspartic acid | NIPPON SHOKUBAI CO., LTD. (JP) | 1995-11-22 | — | — | EP | claimed |
| EP-0680078-A2 | Semiconductor substrate surface treatment | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1995-11-02 | — | — | EP | claimed |
| WO-1995020618-A1 | PRODUCTION OF POLYASPARTIC ACID FROM MALEIC ACID AND AMMONIA | DONLAR CORPORATION (US) | 1995-08-03 | — | — | WO | claimed |
| US-5373088-A | Production of polyaspartic acid from maleic acid and ammonia | DONLAR CORPORATION (US) | 1994-12-13 | — | — | US | claimed |
| US-5371179-A | Polysuccinimide polymers and process for preparing polysuccinimide polymers | ROHM AND HAAS COMPANY (US) | 1994-12-06 | — | — | US | claimed |
| EP-0578451-A2 | Polysuccinimide polymers and process for preparing polysuccinimide polymers | ROHM AND HAAS COMPANY (US) | 1994-01-12 | — | — | EP | claimed |
| US-4623412-A | UREA-ALDEHYDE RESIN, COATING, CURING | CHAMPION INTERNATIONAL CORPORATION (US) | 1986-11-18 | — | — | US | claimed |
| US-4610965-A | Adsorption-desorption purification of glucose isomerase | NABISCO BRANDS, INC. (US) | 1986-09-09 | — | — | US | claimed |
| EP-0185379-A2 | A process for the production of purified glucose isomerase | NABISCO BRANDS, Inc. (US) | 1986-06-25 | — | — | EP | claimed |
| EP-0178903-A2 | Improved tellurium imaging composition and film including imide or ammonium salt | ENERGY CONVERSION DEVICES, INC. (US) | 1986-04-23 | — | — | EP | claimed |