Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Buspirone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 8/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | HTR2A | P28223 | 2/20 | 0.98 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | CNR1 | P21554 | 1/20 | 0.98 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
| ▸ | HTR7 | P34969 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | HRH1 | P35367 | 1/20 | 0.98 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buspirone SCHEMBL10441318 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11880141 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11878911 | 0.99 | ALDH1A1 (0.98) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| Buspirone SCHEMBL16398 | 0.99 | HTR1A (1.00) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| Buspirone SCHEMBL17004050 | 0.99 | HTR1A (1.00) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11877578 | 0.98 | ALDH1A1 (0.95) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| SCHEMBL11875965 | 0.98 | HTR1A (0.98) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| Buspirone SCHEMBL41496 | 0.98 | HTR1A (0.98) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| SCHEMBL11875345 | 0.98 | HTR1A (0.98) | ALDH1A1KDM4EPMP22HTR1ADRD2 | |
| SCHEMBL11881209 | 0.96 | HTR1A (0.95) | ALDH1A1KDM4EPMP22HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2868 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121578093-A | Self-checking method of boost circuit, self-checking method of circuit and device thereof | 上能电气股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| CN-111342836-B | Two-bus code sending driving circuit with protection control function | 深圳市泰和安科技有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-119798224-A | Preparation method of buspirone hydrochloride | 山东京卫制药有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-119409681-A | Preparation method of buspirone hydrochloride | 北京华素制药股份有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-119198934-A | Method and system for detecting residual solvent of buspirone hydrochloride solvent | 武汉海特生物创新医药研究有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-119023833-A | Method and system for detecting related substances of buspirone hydrochloride starting material | 武汉海特生物创新医药研究有限公司 | 2024-11-26 | — | — | CN | claimed |
| CN-118845719-A | Melatonin/buspirone hydrochloride oral instant film agent and preparation method thereof | 沈阳药科大学 | 2024-10-29 | — | — | CN | claimed |
| CN-118702676-A | Preparation method of buspirone hydrochloride crystal form II | 济南大学 | 2024-09-27 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-115065299-B | Neutral point voltage balancing method applied to control of three-level permanent magnet synchronous motor | 冶金自动化研究设计院有限公司 | 2024-08-16 | — | — | CN | claimed |
| EP-0276543-A2 | Use of buspirone for the improvement of short term memory | Bristol-Myers Squibb Company (US) | 1988-08-03 | — | — | EP | claimed |
| EP-0276536-A2 | Use of buspirone for the improvement of short term memory | Bristol-Myers Squibb Company (US) | 1988-08-03 | — | — | EP | claimed |
| US-4687772-A | Method for improvement of short term memory | BRISTOL-MYERS COMPANY (US) | 1987-08-18 | — | — | US | claimed |
| WO-1987004621-A1 | TREATMENT OF SEXUAL DYSFUNCTION WITH BUSPIRONE | OTHMER EKKEHARD (US) | 1987-08-13 | — | — | WO | claimed |
| EP-0220696-A2 | Use of buspirone for preparing pharmaceutical compositions for alleviation of phobic anxiety | Bristol-Myers Squibb Company (US) | 1987-05-06 | — | — | EP | claimed |
| US-4640921-A | GENERALIZED ANXIETY DISORDER | BRISTOL-MYERS (US) | 1987-02-03 | — | — | US | claimed |
| US-4634703-A | Method for alleviation of panic disorders | BRISTOL-MYERS COMPANY (US) | 1987-01-06 | — | — | US | claimed |
| US-4438119-A | BUSPIRONE OR SALTS THEREOF | MEAD JOHNSON & COMPANY (US) | 1984-03-20 | — | — | US | claimed |
| US-4182763-A | PALLIATIVE TREATMENT OF NEUROSES | MEAD JOHNSON & COMPANY (US) | 1980-01-08 | — | — | US | claimed |
| US-3976776-A | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones | MEAD JOHNSON & COMPANY (US) | 1976-08-24 | — | — | US | claimed |