Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5875577 | 0.84 | TGFBR1 (0.48) | TGFBR1MAPK14 | |
| SCHEMBL18005423 | 0.81 | TGFBR1 (1.00) | TGFBR1MAPK14MTOR | |
| SCHEMBL5138951 | 0.78 | TGFBR1 (0.67) | TGFBR1MAPK14MTOR | |
| SCHEMBL4030130 | 0.77 | TGFBR1 (0.63) | TGFBR1MAPK14MTOR | |
| SCHEMBL4032785 | 0.76 | TGFBR1 (0.62) | TGFBR1MAPK14MTOR | |
| SCHEMBL4031270 | 0.76 | TGFBR1 (0.62) | TGFBR1MAPK14MTOR | |
| SCHEMBL15638339 | 0.75 | TGFBR1 (0.81) | TGFBR1MAPK14MTOR | |
| SCHEMBL5875521 | 0.75 | TGFBR1 (0.60) | TGFBR1MAPK14 | |
| SCHEMBL5875566 | 0.74 | TGFBR1 (0.45) | TGFBR1MAPK14 | |
| SCHEMBL4032537 | 0.73 | TGFBR1 (0.58) | TGFBR1MAPK14MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030125-B2 | Isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER, INC. (US) | 2006-04-18 | — | — | US | claimed |
| US-20140120621-A1 | TGF-BETA RECEPTOR INHIBITORS TO ENHANCE DIRECT REPROGRAMMING | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-8603818-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2013-12-10 | — | — | US | disclosed |
| US-8298825-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |
| US-7030125-B2 | Isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| US-20040116473-A1 | Novel isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER INC | 2004-06-17 | — | — | US | disclosed |