Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415014 | 0.84 | TGFBR1 (0.67) | TGFBR1MAPK14 | |
| SCHEMBL5875521 | 0.77 | TGFBR1 (0.60) | TGFBR1MAPK14THRB | |
| SCHEMBL5875566 | 0.75 | TGFBR1 (0.45) | TGFBR1MAPK14KDRTHRB | |
| SCHEMBL20193927 | 0.68 | TGFBR1 (0.68) | TGFBR1 | |
| SCHEMBL21083348 | 0.68 | TGFBR1 (0.69) | TGFBR1MAPK14 | |
| SCHEMBL3242736 | 0.67 | TGFBR1 (0.48) | TGFBR1MAPK14 | |
| SCHEMBL24151244 | 0.67 | TGFBR1 (0.53) | TGFBR1MAPK14KDR | |
| SCHEMBL18970606 | 0.66 | DYRK1B (0.48) | TGFBR1DYRK1B | |
| SCHEMBL29796522 | 0.66 | TGFBR1 (0.47) | TGFBR1MAPK14 | |
| SCHEMBL23389918 | 0.66 | TGFBR1 (0.47) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030125-B2 | Isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1542995-A1 | NOVEL ISOTHIAZOLE AND ISOXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116473-A1 | Novel isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER INC | 2004-06-17 | — | — | US | disclosed |
| WO-2004026865-A1 | NOVEL ISOTHIAZOLE AND ISOXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |