Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5875521 | 0.83 | TGFBR1 (0.60) | TGFBR1MAPK14THRBTGFBR2CSNK1A1 | |
| SCHEMBL6683670 | 0.82 | TGFBR1 (0.48) | TGFBR1MAPK14KDM4EMAPK1NPSR1 | |
| SCHEMBL5875577 | 0.75 | TGFBR1 (0.48) | TGFBR1MAPK14KDRTHRB | |
| SCHEMBL415014 | 0.74 | TGFBR1 (0.67) | TGFBR1MAPK14 | |
| SCHEMBL23852538 | 0.73 | TGFBR1 (0.81) | TGFBR1MAPK14KDRTHRBGAK | |
| SCHEMBL31461240 | 0.73 | TGFBR1 (0.81) | TGFBR1MAPK14KDRTHRBGAK | |
| SCHEMBL2049534 | 0.70 | TGFBR1 (0.60) | TGFBR1MAPK14KDRTHRBGAK | |
| SCHEMBL4863433 | 0.68 | TGFBR1 (0.58) | TGFBR1MAPK14KDRTHRBGAK | |
| SCHEMBL2044086 | 0.67 | TGFBR1 (0.49) | TGFBR1MAPK14KDRTHRBGAK | |
| SCHEMBL30440258 | 0.67 | PIK3CA (0.57) | KDM4EMAPK1NPSR1LMNAMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030125-B2 | Isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1542995-A1 | NOVEL ISOTHIAZOLE AND ISOXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116473-A1 | Novel isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors | PFIZER INC | 2004-06-17 | — | — | US | disclosed |
| WO-2004026865-A1 | NOVEL ISOTHIAZOLE AND ISOXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |