Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.57 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.57 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12578181 | 0.91 | GNAI3 (0.47) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL12015005 | 0.84 | NPC1 (0.47) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL12197910 | 0.84 | NPC1 (0.67) | NPC1ALDH1A1 | |
| SCHEMBL22874723 | 0.82 | NPC1 (0.46) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL12413725 | 0.81 | POLB (0.51) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL1562717 | 0.79 | GNAI3 (0.72) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL12018620 | 0.79 | NPC1 (0.43) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL3315105 | 0.79 | NPC1 (0.43) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL31370057 | 0.79 | CACNA1B (0.56) | GNAI3GNAO1GNAI1CACNA1BNPC1 | |
| SCHEMBL12197900 | 0.79 | ATM (0.58) | NPC1CNR1CNR2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080665-B2 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-12-20 | — | — | US | disclosed |
| US-20090124660-A1 | Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-05-14 | — | — | US | disclosed |
| US-7449482-B2 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-11-11 | — | — | US | disclosed |
| EP-1653957-B1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-07-09 | — | — | EP | disclosed |
| EP-1653957-A1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011693-A1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | disclosed |
| US-20050032828-A1 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032828-A1 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, PC | GNAI3 3259/4885GNAO1 3542/4885GNAI1 2728/4885 |
| US-20090124660-A1 | Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors | ACACA, ACACB, PC | GNAI3 3259/4885GNAO1 3542/4885GNAI1 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.