Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 4/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 4/20 | 0.40 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311863 | 0.73 | CYP46A1 (0.44) | P2RX3P2RX2CYP46A1KDM1AHDAC1 | |
| SCHEMBL3067373 | 0.73 | NOTUM (0.47) | CYP46A1KDM1AHDAC1HDAC6PTGS2 | |
| SCHEMBL3661320 | 0.72 | CYP46A1 (0.40) | P2RX3P2RX2CYP46A1KDM1AHDAC1 | |
| SCHEMBL406883 | 0.70 | CYP46A1 (0.43) | CYP46A1KDM1AHDAC1HDAC6NPC1 | |
| SCHEMBL3075053 | 0.70 | HDAC1 (0.46) | P2RX3P2RX2CYP46A1KDM1AHDAC1 | |
| SCHEMBL3662590 | 0.68 | NOTUM (0.41) | CYP46A1KDM1AHDAC1HDAC6PTGS2 | |
| SCHEMBL16510107 | 0.65 | P2RX3 (0.45) | P2RX3P2RX2KDM1AHDAC1HDAC6 | |
| SCHEMBL4214130 | 0.64 | MAPK1 (0.49) | CYP46A1KDM1AHDAC1HDAC6PDGFRB | |
| SCHEMBL2260726 | 0.64 | CYP46A1 (0.45) | CYP46A1KDM1AHDAC1HDAC6NPC1 | |
| SCHEMBL13092857 | 0.64 | P2RX3 (0.42) | P2RX3P2RX2KDM1AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440673-B2 | Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2013-05-14 | — | — | US | disclosed |
| US-20090170873-A1 | Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170873-A1 | Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists | P2RX3, P2RX2, P2RX7 | P2RX3 1/4885P2RX2 2/4885CYP46A1 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.