Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of E-Doxepin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.97 |
| ▸ | HTR1A | P08908 | 2/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | DRD2 | P14416 | 2/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxepin SCHEMBL1281891 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL3408702 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL29368454 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL29359800 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL41532 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL124597 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL29018844 | 0.99 | ALDH1A1 (0.97) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Cidoxepin SCHEMBL684837 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL31349647 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B | |
| Doxepin SCHEMBL28054 | 0.99 | HTR2B (1.00) | ALDH1A1KDM4EPMP22RECQLHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3010 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| WO-2025024501-A1 | NEUROMODULATORY PEPTIDES | LACTOCORE, INC. (US) | 2025-01-30 | — | — | WO | claimed |
| CN-113573723-B | Synthetic neuromodulatory peptides | 拉托科公司 | 2024-12-03 | — | — | CN | claimed |
| US-20240307386-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. | 2024-09-19 | — | — | US | claimed |
| EP-4297868-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | Hoth Therapeutics, Inc. (US) | 2024-01-03 | — | — | EP | claimed |
| US-20230381168-A1 | ADJUNCTIVE THERAPY FOR DEPRESSION | ANEUROTECH BV (BE) | 2023-11-30 | — | — | US | claimed |
| US-20230140798-A1 | SYNTHETIC PEPTIDES DIRECTED AGAINST THE METABOTROPIC GLUTAMATE RECEPTOR 5 | LACTOCORE INC (US) | 2023-05-04 | — | — | US | claimed |
| CN-115884790-A | Therapeutic combinations of drugs and methods of use thereof | 康圣博施医药有限公司 | 2023-03-31 | — | — | CN | claimed |
| US-20230084144-A1 | THERAPEUTIC COMBINATIONS OF DRUGS AND METHODS OF USING THEM | CONSYNANCE THERAPEUTICS INC (US) | 2023-03-16 | — | — | US | claimed |
| EP-4135741-A1 | SYNTHETIC PEPTIDES FOR MODULATING THE METABOTROPIC GLUTAMATE RECEPTOR 5 | Lactocore, Inc. (US) | 2023-02-22 | — | — | EP | claimed |
| WO-2006078524-A1 | METHODS FOR QT INTERVAL CONTROL | JANSSEN PHARMACUTICA, N.V. (BE) | 2006-07-27 | — | — | WO | claimed |
| WO-2005112927-A1 | SELECTIVE SEROTONIN RECEPTOR INVERSE AGONISTS AS THERAPEUTICS FOR DISEASE | ACADIA PHARMACEUTICALS INC. (US) | 2005-12-01 | — | — | WO | claimed |
| US-20050261278-A1 | Selective serotonin receptor inverse agonists as therapeutics for disease | ACADIA PHARMACEUTICALS INC. | 2005-11-24 | — | — | US | claimed |
| WO-2005098429-A2 | SYSTEM AND METHOD FOR REAL-TIME DIAGNOSIS, TREATMENT, AND THERAPEUTIC DRUG MONITORING | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2005-10-20 | — | — | WO | claimed |
| US-20050233459-A1 | Marker detection method and apparatus to monitor drug compliance | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2005-10-20 | — | — | US | claimed |
| WO-2005051389-A1 | USING OF (+)-ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1,4-DIHYDRO-2,6-DYMETHYL-PYRIDINE-3,5-DICARBOXYLATE IN THE TREATMENT OF MEMORY DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-06-09 | — | — | WO | claimed |
| US-20050054942-A1 | System and method for therapeutic drug monitoring | UNIVERSITY OF FLORIDA | 2005-03-10 | — | — | US | claimed |
| US-20040092511-A1 | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders | BILLSTEIN STEPHAN ANTHONY (US) | 2004-05-13 | — | — | US | claimed |
| WO-2002085297-A2 | COMPOSITIONS & FORMULATIONS WITH A NON-GLUCOCORTICOID STEROID &/OR A UBIQUINONE & KIT FOR TREATMENT OF RESPIRATORY & LUNG DISEASE | EAST CAROLINA UNIVERSITY (US) | 2002-10-31 | — | — | WO | claimed |
| US-4539199-A | AMINE SALT OF ACRYLIC ACID-ACRYLIC ESTER COPOLYMER | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1985-09-03 | — | — | US | claimed |