Sugi Predict

Sugi Predict / Compounds / SCHEMBL4153267

SCHEMBL4153267

SCHEMBL4153267

C=Cc1cccc(C(C)=O)c1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 0.50
▸ TP53 P04637 1/20 0.50
▸ MEN1 O00255 4/20 0.46
▸ KMT2A Q03164 4/20 0.46
▸ ALDH1A1 P00352 4/20 0.46
▸ UNG P13051 1/20 0.46
▸ PTGS2 P35354 1/20 0.44
▸ CREBBP Q92793 2/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ BRD4 O60885 1/20 0.41
▸ BRD2 P25440 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ POLB P06746 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ TTR P02766 1/20 0.40
▸ MAOB P27338 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29838039 1.00 TDP1 (0.50) TDP1TP53MEN1KMT2AALDH1A1
Furan SCHEMBL27649322 0.90 TDP1 (0.42) TDP1TP53MEN1KMT2AALDH1A1
SCHEMBL18717428 0.89 PTGS2 (0.54) TDP1TP53PTGS2CREBBPBRD4
SCHEMBL28242748 0.83 TDP1 (0.52) TDP1TP53ALDH1A1UNGPTGS2
SCHEMBL16956341 0.83 TP53 (0.54) TDP1TP53MEN1KMT2AALDH1A1
SCHEMBL11465197 0.83 MEN1 (0.49) TDP1MEN1KMT2AALDH1A1UNG
SCHEMBL1482839 0.82 UNG (0.68) TDP1MEN1KMT2AALDH1A1UNG
SCHEMBL15036 0.82 UNG (0.68) TDP1TP53ALDH1A1UNGTTR
SCHEMBL21777904 0.82 UNG (0.68) TDP1TP53ALDH1A1UNGTTR
SCHEMBL9333647 0.82 TDP1 (0.52) TDP1TP53ALDH1A1UNGPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230046628-A1 Macromolecular compositions for binding small molecules STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-02-16 — — US claimed
EP-4061859-A1 MACROMOLECULAR COMPOSITIONS FOR BINDING SMALL MOLECULES Stichting voor de Technische Wetenschappen (NL) 2022-09-28 — — EP claimed
WO-2021099577-A1 MACROMOLECULAR COMPOSITIONS FOR BINDING SMALL MOLECULES STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2021-05-27 — — WO claimed
CN-104387385-A 6-carboxylmethyl-2-oxo-7-azaindole as well as preparation method and application of 6-carboxylmethyl-2-oxo-7-azaindole SUZHOU HEJIAN MEDICAL TECHNOLOGY CO LTD 2015-03-04 — — CN claimed
CN-119013320-A High MFR polypropylene for melt blown nonwoven applications 格雷斯公司 2024-11-22 — — CN disclosed
EP-3500362-B1 METAL ION EXTRACTION FROM BRINES EXSORBTION INC (US) 2024-03-06 — — EP disclosed
US-20230046628-A1 Macromolecular compositions for binding small molecules STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-02-16 — — US disclosed
US-20230046628-A1 Macromolecular compositions for binding small molecules STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-02-16 — — US disclosed
CN-115279802-A Macromolecular compositions for binding small molecules 德国科技术基金会 2022-11-01 — — CN disclosed
EP-4061859-A1 MACROMOLECULAR COMPOSITIONS FOR BINDING SMALL MOLECULES Stichting voor de Technische Wetenschappen (NL) 2022-09-28 — — EP disclosed
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 — — CN disclosed
CN-109715288-B Extraction of metal ions from brine 爱克斯司博申公司 2022-06-17 — — CN disclosed
US-20090018177-A1 Propane-1,3-Dione Derivative or Salt Thereof ASTELLAS PHARMA INC. (JP) 2009-01-15 — — US disclosed
US-7429609-B2 Pyrazole compound and medicinal composition containing the same EISAI R & D MANAGEMENT CO., LTD. (JP) 2008-09-30 — — US disclosed
US-20060241132-A1 Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient TORAY INDUSTRIES, INC. A CORPORATION OF JAPAN (JP) 2006-10-26 — — US disclosed
US-20050261339-A1 Pyrazole compound and medicinal composition containing the same EISAI R&D MANAGEMENT CO., LTD. (JP) 2005-11-24 — — US disclosed
US-20050208582-A1 Pyrazole compounds and pharmaceutical compositions comprising the compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2005-09-22 — — US disclosed
EP-1510516-A1 PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME Eisai Co., Ltd. (JP) 2005-03-02 — — EP disclosed
EP-1489081-A1 SPIRO DERIVATIVES AND ADHESION MOLECULE INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT TORAY INDUSTRIES, INC. (JP) 2004-12-22 — — EP disclosed
US-4120909-A DEHYDRATION OF METHYL PHENYL KETONES, CATALYST HERCULES INCORPORATED (US) 1978-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018177-A1 Propane-1,3-Dione Derivative or Salt Thereof GPER1, GNRHR, AR TDP1 1945/4885TP53 1210/4885MEN1 538/4885
US-20050261339-A1 Pyrazole compound and medicinal composition containing the same CNKSR1, NR3C2, CSNK2B TDP1 4458/4885TP53 1057/4885MEN1 4470/4885
US-20060241132-A1 Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient VCAM1, SELL, ICAM1 TDP1 4713/4885TP53 3634/4885MEN1 4337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.