Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.56 |
| ▸ | CASP6 | P55212 | 2/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4148082 | 0.83 | MAPT (0.70) | LMNAMAPTALDH1A1CASP7CASP6 | |
| SCHEMBL5835722 | 0.83 | MTNR1A (0.54) | LMNAMAPTALDH1A1CDK2CDK5 | |
| SCHEMBL1395185 | 0.77 | ATG4B (0.74) | LMNAMAPTALDH1A1CASP7CASP6 | |
| SCHEMBL15727740 | 0.76 | GLS (0.66) | LMNAMTNR1AMTNR1BKDM4E | |
| SCHEMBL13774680 | 0.74 | KMT2A (0.65) | LMNAMAPTALDH1A1CASP7CASP6 | |
| SCHEMBL8252641 | 0.74 | KDM4E (0.73) | ALDH1A1MTNR1AMTNR1BKDM4EMEN1 | |
| SCHEMBL5239218 | 0.74 | KDM4E (0.73) | ALDH1A1MTNR1AMTNR1BKDM4EMEN1 | |
| SCHEMBL21443481 | 0.73 | GLS (0.61) | LMNAMTNR1AMTNR1BKDM4E | |
| SCHEMBL15742597 | 0.73 | GLS (0.61) | LMNAALDH1A1MTNR1AMTNR1BKDM4E | |
| SCHEMBL13774678 | 0.73 | PLCG2 (0.59) | MAPTALDH1A1ATG4BRPS6KB1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192204-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS | NOSCIRA, S.A. (ES) | 2009-07-30 | — | — | US | disclosed |
| US-20090192204-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS | NOSCIRA, S.A. (ES) | 2009-07-30 | — | — | US | disclosed |
| US-20090192204-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS | NOSCIRA, S.A. (ES) | 2009-07-30 | — | — | US | disclosed |
| EP-2019828-A1 | N- (2-THIAZOLYL) -AMIDE DERIVATIVES AS GSK-3 INHIBITORS | Noscira, S.A. (ES) | 2009-02-04 | — | — | EP | disclosed |
| WO-2007125109-A1 | N- (2-THIAZOLYL) -AMIDE DERIVATIVES AS GSK-3 INHIBITORS | NOSCIRA, S.A. (ES) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007125109-A1 | N- (2-THIAZOLYL) -AMIDE DERIVATIVES AS GSK-3 INHIBITORS | NOSCIRA, S.A. (ES) | 2007-11-08 | — | — | WO | disclosed |
| EP-1849785-A1 | N-(2-Thiazolyl)-amide derivatives as GSK-3 inhibitors | Neuropharma, S.A. (ES) | 2007-10-31 | — | — | EP | disclosed |
| EP-1849785-A1 | N-(2-Thiazolyl)-amide derivatives as GSK-3 inhibitors | Neuropharma, S.A. (ES) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192204-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS | GSK3B, GSK3A, GSKIP | LMNA 1384/4885MAPT 10/4885ALDH1A1 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.