Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722986 | 0.91 | SYK (0.50) | LTA4HPOLBCYP2D6KDM4EHTR2C | |
| SCHEMBL723902 | 0.90 | LTA4H (0.42) | LTA4HCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL2797649 | 0.85 | TSHR (0.52) | CYP1A2CYP2D6SMN1; SMN2KDM4EHTR2A | |
| SCHEMBL3561000 | 0.85 | LTA4H (0.50) | LTA4HCYP1A2CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL28672933 | 0.82 | MEN1 (0.41) | MCHR1CYP1A2CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL183050 | 0.81 | CSF1R (0.41) | POLBCYP2C19 | |
| SCHEMBL871366 | 0.80 | LTA4H (0.54) | LTA4HKDM4E | |
| SCHEMBL20562815 | 0.80 | MEN1 (0.42) | POLB | |
| SCHEMBL22265010 | 0.79 | ACHE (0.48) | CYP1A2CYP2D6CYP2C19HSD17B10SMN1; SMN2 | |
| SCHEMBL17427861 | 0.79 | KDM4E (0.54) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2810937-B1 | PYRIDONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2016-11-30 | — | — | EP | disclosed |
| US-8933103-B2 | Pyridone derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-13 | — | — | US | disclosed |
| EP-2810937-A1 | PYRIDONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-10 | — | — | EP | disclosed |
| US-20130281428-A1 | Pyridone Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-10-24 | — | — | US | disclosed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281428-A1 | Pyridone Derivatives | AXL, PDXK, TYRO3 | LTA4H 3208/4885POLB 4369/4885MCHR1 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.