Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 3/20 | 0.54 |
| ▸ | SELE | P16581 | 3/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161369 | 0.84 | CYP3A4 (0.42) | ICAM1SELEPARP1PARP15PARP14 | |
| SCHEMBL4148474 | 0.82 | CDK1 (0.54) | ICAM1SELEPARP1PARP15PARP14 | |
| SCHEMBL4156126 | 0.82 | ICAM1 (0.54) | ICAM1SELEPARP1PARP15PARP14 | |
| SCHEMBL4144009 | 0.81 | PARP10 (0.50) | ICAM1SELEPARP1PARP15PARP14 | |
| SCHEMBL4154998 | 0.79 | PRSS1 (0.43) | ICAM1SELEPARP15PARP14PARP10 | |
| SCHEMBL4150602 | 0.76 | SPHK2 (0.51) | PARP10KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1680519 | 0.73 | MAOB (0.39) | ICAM1SELEKMT2ACYP1A2CYP2C9 | |
| SCHEMBL4155072 | 0.72 | ICAM1 (0.49) | ICAM1SELEPARP15PARP14PARP10 | |
| SCHEMBL4159295 | 0.72 | IKBKB (0.54) | ICAM1SELEPARP15PARP14PARP10 | |
| SCHEMBL28541614 | 0.71 | EPHX2 (0.58) | PARP1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227799-A1 | Novel Antimalarial Agent Containing Heterocyclic Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| EP-1782811-A1 | NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1669348-A1 | NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 2006-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227799-A1 | Novel Antimalarial Agent Containing Heterocyclic Compound | XPO1, THPO, G6PD | ICAM1 4352/4885SELE 3545/4885PARP1 992/4885 |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | ERG28, DPM1, CYP51A1 | ICAM1 4405/4885SELE 4499/4885PARP1 3078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.