Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143684 | 0.82 | PARP1 (0.43) | L3MBTL1PARP1FGFR1FGFR2GRM5 | |
| SCHEMBL13851590 | 0.74 | TNKS2 (0.45) | PARP1FGFR1FGFR2ALDH1A1GRM5 | |
| SCHEMBL4152598 | 0.72 | FGFR1 (0.46) | L3MBTL1PARP1FGFR1FGFR2ALDH1A1 | |
| SCHEMBL30667675 | 0.71 | PDE4B (0.39) | ALDH1A1ALOX15HSD17B10PDE4APDE4B | |
| SCHEMBL31139409 | 0.71 | MEN1 (0.46) | L3MBTL1ALDH1A1GAAHSD17B10PDE4A | |
| SCHEMBL4141949 | 0.71 | FGFR1 (0.45) | L3MBTL1PARP1FGFR1FGFR2ALDH1A1 | |
| SCHEMBL26088831 | 0.70 | NOTUM (0.44) | PARP1ALDH1A1GRM5GRM1PIM1 | |
| SCHEMBL31139453 | 0.70 | NOTUM (0.44) | PARP1ALDH1A1GRM5GRM1PIM1 | |
| SCHEMBL4135896 | 0.70 | TP53 (0.43) | GAAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21065142 | 0.69 | TSHR (0.44) | L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | L3MBTL1 4809/4885PARP1 3786/4885FGFR1 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.