Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169765 | 1.00 | MEN1 (0.64) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL4156605 | 1.00 | MEN1 (0.64) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5424614 | 0.89 | MAPT (0.62) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5424606 | 0.89 | MAPT (0.62) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5427228 | 0.88 | KMT2A (0.60) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5427234 | 0.88 | KMT2A (0.60) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5416313 | 0.86 | MAPT (0.71) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5416306 | 0.86 | MAPT (0.71) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL4165339 | 0.83 | CYP3A4 (0.76) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL4165350 | 0.83 | CYP3A4 (0.76) | MEN1KMT2AMAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233913-A1 | OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) | 2009-09-17 | — | — | US | claimed |
| US-20090233913-A1 | OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) | 2009-09-17 | — | — | US | disclosed |
| EP-1979308-A1 | OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS | EGIS Gyógyszergyár Nyrt (HU) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007077469-A1 | OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS | EGIS GYÓGYSZERGYÁR (HU) | 2007-07-12 | — | — | WO | disclosed |
| US-7053082-B1 | 2,3-benzodiazepine derivatives | EGIS GYOGYSZERGYAR RT. (HU) | 2006-05-30 | — | — | US | disclosed |
| EP-1200442-B8 | 2,3-BENZODIAZEPINE DERIVATIVES | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-08-20 | — | — | EP | disclosed |
| EP-1200442-B1 | 2,3-BENZODIAZEPINE DERIVATIVES | EGIS GY GYSZERGY R RT (HU) | 2003-06-25 | — | — | EP | disclosed |
| EP-1200442-A1 | 2,3-BENZODIAZEPINE DERIVATIVES | Egis Gyogyszergyar Rt. (HU) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004122-A2 | NEW 2,3-BENZODIAZEPINE DERIVATIVES | EGIS Gyógyszergyár Rt. (HU) | 2001-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233913-A1 | OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS | GABRA2, GABRA3, GABRB2 | MEN1 4648/4885KMT2A 925/4885MAPT 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.