Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.68 |
| ▸ | BCHE | P06276 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13814798 | 0.85 | BCHE (0.67) | ACHEBCHEKMT2AHDAC3HDAC4 | |
| SCHEMBL4166609 | 0.82 | KMT2A (0.56) | ACHEBCHEKMT2ASIGMAR1KDM4E | |
| SCHEMBL7732370 | 0.82 | KDM4E (0.67) | ACHEBCHEKMT2AKDM4EFAAH | |
| SCHEMBL11396437 | 0.82 | MGLL (0.62) | ACHEBCHEKMT2AHDAC3HDAC4 | |
| SCHEMBL11396531 | 0.82 | HSD11B1 (0.62) | ACHEBCHEKMT2AHDAC3HDAC4 | |
| SCHEMBL11396899 | 0.82 | ACHE (0.57) | ACHEBCHEKMT2AHDAC3HDAC4 | |
| SCHEMBL28946798 | 0.82 | KMT2A (0.69) | ACHEBCHEKMT2AKDM4EALDH1A1 | |
| SCHEMBL7493236 | 0.82 | KMT2A (0.69) | ACHEBCHEKMT2AHDAC3HDAC4 | |
| SCHEMBL1314889 | 0.81 | ACHE (0.47) | ACHEBCHEHDAC3HDAC4HDAC1 | |
| SCHEMBL5763722 | 0.81 | BCHE (0.63) | ACHEBCHEKMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143429-A1 | Quinoline Derivatives as Neurokinin Receptor Antagonists | CRAWFORTH JAMES MICHAEL | 2009-06-04 | — | — | US | disclosed |
| EP-1912967-A1 | QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007012900-A1 | QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2007-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143429-A1 | Quinoline Derivatives as Neurokinin Receptor Antagonists | TACR2, TACR1, TACR3 | ACHE 657/4885BCHE 2227/4885KMT2A 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.