Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.55 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5113224 | 0.85 | PARP15 (0.48) | KDM5AKDM5BPARP15TNKS2PARP10 | |
| SCHEMBL4158228 | 0.80 | KDM5A (0.56) | KDM5AKDM5BKDM4ELMNAALDH1A1 | |
| SCHEMBL14208480 | 0.78 | MEN1 (0.54) | PARP15TNKS2PARP10LMNAALDH1A1 | |
| SCHEMBL4703123 | 0.77 | KDM5A (0.60) | KDM5AKDM5BKDM4ELMNAALDH1A1 | |
| SCHEMBL4155315 | 0.76 | ALDH1A1 (0.50) | KDM5AKDM5BKDM4ELMNAALDH1A1 | |
| SCHEMBL1058188 | 0.75 | KDM5A (0.68) | KDM5AKDM5BKDM4ELMNAALDH1A1 | |
| SCHEMBL5330015 | 0.75 | KDM5A (0.64) | KDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL15966771 | 0.74 | KDM5A (0.59) | KDM5AKDM5BKDM4EALDH1A1GAA | |
| SCHEMBL1242308 | 0.73 | HPGD (0.43) | PARP15TNKS2PARP10KDM4EALDH1A1 | |
| SCHEMBL5526950 | 0.73 | KDM5A (0.62) | KDM5AKDM5BKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176825-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-07-09 | — | — | US | disclosed |
| US-20080139551-A1 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2008-06-12 | — | — | US | disclosed |
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365200-B2 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS (US) | 2008-04-29 | — | — | US | disclosed |
| EP-1861407-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-12-05 | — | — | EP | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2007-08-02 | — | — | US | disclosed |
| US-20060229314-A1 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | AVANIR PHARMACEUTICALS | 2006-10-12 | — | — | US | disclosed |
| WO-2006102191-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | AVANIR PHARMACEUTICALS (US) | 2006-09-28 | — | — | WO | disclosed |
| EP-0505058-B1 | Thienopyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1997-05-21 | — | — | EP | disclosed |
| EP-0503844-B1 | Thienopyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1994-08-03 | — | — | EP | disclosed |
| US-5219864-A | Prevention, treatment of osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-15 | — | — | US | disclosed |
| US-5155115-A | THIENOPYRIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0505058-A1 | Thienopyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0503844-A1 | Thienopyridine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179149-A1 | THIENOPYRIDINONE DERIVATIVES AS MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | MIF, MMP12, MSR1 | KDM5A 2405/4885KDM5B 2307/4885PARP15 3706/4885 |
| US-20080139551-A1 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | TNF, TNFRSF1A, TNFRSF9 | KDM5A 4732/4885KDM5B 4749/4885PARP15 4726/4885 |
| US-20060229314-A1 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors | MIF, MMP12, MSR1 | KDM5A 2405/4885KDM5B 2307/4885PARP15 3706/4885 |
| US-20090176825-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN2, EGLN3 | KDM5A 495/4885KDM5B 588/4885PARP15 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.