Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20452290 | 0.81 | ALDH1A1 (0.65) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4161633 | 0.81 | ALDH1A1 (0.53) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4164804 | 0.80 | RAB9A (0.63) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4159119 | 0.78 | ALDH1A1 (0.58) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL20452073 | 0.78 | ALDH1A1 (0.58) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4167891 | 0.77 | NPC1 (0.71) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL4159231 | 0.74 | KDM4E (0.43) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| SCHEMBL4166890 | 0.73 | RAB9A (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL20452082 | 0.73 | RAB9A (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5163250 | 0.73 | ALDH1A1 (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | ALDH1A1 2743/4885RAB9A 2128/4885NPC1 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.