Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161630 | 0.81 | NR4A2 (0.31) | KDM4EALDH1A1MAPTMAPK1NR4A2 | |
| SCHEMBL4164802 | 0.80 | NPC1 (0.52) | KDM4EALDH1A1MAPTNPC1HSD17B10 | |
| SCHEMBL4159114 | 0.78 | NR4A2 (0.33) | KDM4EALDH1A1MAPTMAPK1RAB9A | |
| SCHEMBL4167886 | 0.77 | NPC1 (0.65) | KDM4EALDH1A1POLBMAPTNPC1 | |
| SCHEMBL4159233 | 0.74 | ALDH1A1 (0.65) | KDM4EALDH1A1ADORA2AADORA1POLB | |
| SCHEMBL4166886 | 0.73 | RAB9A (0.51) | KDM4EALDH1A1ADORA2APOLBMAPT | |
| SCHEMBL4173588 | 0.72 | PTGS2 (0.38) | KDM4EALDH1A1POLBMAPTNPC1 | |
| SCHEMBL4161696 | 0.72 | CCNC (0.39) | KDM4EALDH1A1MAPTNPC1HSD17B10 | |
| SCHEMBL25691020 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1ADORA2AADORA1POLB | |
| SCHEMBL2076088 | 0.72 | NR4A2 (0.35) | KDM4EALDH1A1POLBMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | KDM4E 2234/4885ALDH1A1 2743/4885ADORA2A 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.