Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761089 | 0.82 | PTK2 (0.62) | RAB9AMAPTL3MBTL1PTK2SMN1; SMN2 | |
| SCHEMBL6625494 | 0.82 | RAB9A (0.43) | RAB9AMAPTL3MBTL1HCAR3PTK2 | |
| Methane SCHEMBL29283547 | 0.81 | PTK2 (0.61) | RAB9AMAPTL3MBTL1PTK2SMN1; SMN2 | |
| SCHEMBL28522128 | 0.79 | L3MBTL1 (0.49) | RAB9AMAPTL3MBTL1HCAR3PTK2 | |
| SCHEMBL20639917 | 0.79 | L3MBTL1 (0.49) | RAB9AMAPTL3MBTL1PTK2SMN1; SMN2 | |
| SCHEMBL28513546 | 0.79 | RAB9A (0.62) | RAB9AL3MBTL1TSHRSMN1; SMN2TP53 | |
| SCHEMBL3408832 | 0.79 | TSHR (0.68) | RAB9AL3MBTL1TSHRSMN1; SMN2DEGS1 | |
| SCHEMBL4164891 | 0.79 | RAB9A (0.50) | RAB9AL3MBTL1TSHRSMN1; SMN2DEGS1 | |
| SCHEMBL16230884 | 0.78 | TSHR (0.46) | RAB9AMAPTL3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL12903841 | 0.78 | KDM4E (0.41) | RAB9AMAPTL3MBTL1PTK2DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
| EP-1828180-A1 | 1H-PYRROLO[2,3-BETA]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063167-A1 | 1H-PYRROLO[2,3-B]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | RAB9A 2815/4885MAPT 1732/4885L3MBTL1 4480/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | RAB9A 2629/4885MAPT 1717/4885L3MBTL1 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.