SCHEMBL4160241

SCHEMBL4160241

CC(=O)NCC1CN(c2ccc(-c3ccc(N4CCSCC4)nc3)c(F)c2)C(=O)O1

nearest known ligand 0.70

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.70
MAOB P27338 2/20 0.70
CALML3 P27482 4/20 0.56
LMNA P02545 1/20 0.56
PTGS1 P23219 1/20 0.56
SDHA P31040 1/20 0.56
F10 P00742 3/20 0.55
CYP3A4 P08684 1/20 0.50
CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4160239 1.00 MAOA (0.70) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4168134 0.92 MAOA (0.58) MAOAMAOBCALML3F10CYP3A4
SCHEMBL4170119 0.92 MAOA (0.58) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4168138 0.92 MAOA (0.58) MAOAMAOBCALML3F10CYP3A4
SCHEMBL4170115 0.92 MAOA (0.58) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4708190 0.91 MAOA (0.66) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4171585 0.91 MAOA (0.61) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4180294 0.91 MAOA (0.71) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4180297 0.91 MAOA (0.71) MAOAMAOBCALML3LMNAPTGS1
SCHEMBL4171562 0.91 MAOA (0.61) MAOAMAOBCALML3LMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US claimed
EP-1912980-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION Wockhardt Limited (IN) 2008-04-23 EP claimed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO claimed
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed
EP-1912980-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION Wockhardt Limited (IN) 2008-04-23 EP disclosed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation POLL, POLM, POLRMT MAOA 3788/4885MAOB 3240/4885CALML3 4576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.