Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587531 | 0.80 | ADRA2C (0.49) | ADRA2CHTR3AKDM4EGAAMAPT | |
| SCHEMBL5884761 | 0.80 | HTR3A (0.51) | ADRA2CHTR3ASIRT6KDM4EGAA | |
| SCHEMBL1639407 | 0.79 | PRKDC (0.47) | KDM4EMAPTMAPK1HTTKMT2A | |
| SCHEMBL591377 | 0.79 | ADRA2C (0.56) | ADRA2CHTR3ASIRT6KDM4EGAA | |
| SCHEMBL3511994 | 0.79 | ADRA2C (0.47) | ADRA2CHTR3AKDM4EGAAMAPT | |
| SCHEMBL15475119 | 0.79 | ADRA2C (0.47) | ADRA2CHTR3ASIRT6KDM4EGAA | |
| SCHEMBL4165953 | 0.76 | ADRA2C (0.45) | ADRA2CHTR3ASIRT6KDM4EGAA | |
| SCHEMBL28701655 | 0.75 | SIRT6 (0.46) | ADRA2CHTR3ASIRT6KDM4EGAA | |
| SCHEMBL15474579 | 0.73 | CHKA (0.45) | ADRA2CHTR3AKDM4EGAAMAPT | |
| SCHEMBL589356 | 0.73 | SIRT6 (0.55) | SIRT6MAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101563351-A | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-10-21 | — | — | CN | disclosed |
| US-20090099167-A1 | Organic compounds | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH | 2009-04-16 | — | — | US | disclosed |
| US-20050222171-A1 | Organic compounds | NOVARTIS AG (CH) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222171-A1 | Organic compounds | JAK1, MAP3K5, MAP3K7 | ADRA2C 842/4885HTR3A 1484/4885SIRT6 2923/4885 |
| US-20090099167-A1 | Organic compounds | JAK1, MAP3K5, MAP3K7 | ADRA2C 842/4885HTR3A 1484/4885SIRT6 2923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.