Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8040237 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28209583 | 0.94 | — | — | |
| Bicarbonate SCHEMBL29061109 | 0.94 | CA4 (0.67) | — | |
| Bicarbonate SCHEMBL28582066 | 0.94 | CA4 (0.67) | — | |
| Bicarbonate SCHEMBL714912 | 0.94 | CA4 (0.67) | — | |
| Bicarbonate SCHEMBL1331273 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2121875 | 0.94 | CA4 (0.67) | — | |
| Bicarbonate SCHEMBL25 | 0.94 | — | — | |
| Bicarbonate SCHEMBL1331459 | 0.94 | — | — | |
| Bicarbonate SCHEMBL23849739 | 0.88 | CA4 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111988-A1 | NOVEL PROCESS FOR PRODUCTION OF 5--6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE (ZIPRASIDONE) | RICHTER GEDEON NYRT. (HU) | 2009-04-30 | — | — | US | disclosed |
| EP-2013203-A2 | NOVEL PROCESS FOR PRODUCTION OF 5-{2-Ý4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL¨-ETHYL}-6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE (ZIPRASIDONE) | Richter Gedeon NYRT (HU) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007125374-A2 | NOVEL PROCESS FOR PRODUCTION OF 5-{2-[4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL]-ETHYL}-6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE (ZIPRASIDONE) | RICHTER GEDEON NYRT. (HU) | 2007-11-08 | — | — | WO | disclosed |