Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.67 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL25 | 1.00 | — | — | |
| Bicarbonate SCHEMBL29061109 | 1.00 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL28582066 | 1.00 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1331273 | 1.00 | — | — | |
| Bicarbonate SCHEMBL2121875 | 1.00 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1331459 | 1.00 | — | — | |
| Bicarbonate SCHEMBL23849739 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL17477711 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL8206114 | 0.94 | — | — | |
| Bicarbonate SCHEMBL77648 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250057161-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | ADAMA MAKHTESHIM LTD. (IL) | 2025-02-20 | — | — | US | disclosed |
| US-12127559-B2 | Use of cyclodextrins as agrochemical delivery system | ADAMA MAKHTESHIM LTD. (IL) | 2024-10-29 | — | — | US | disclosed |
| WO-2024143387-A1 | ADSORPTION AGENT | 東洋紡株式会社 | 2024-07-04 | — | — | WO | disclosed |
| US-20210386067-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | ADAMA MAKHTESHIM LTD. (IL) | 2021-12-16 | — | — | US | disclosed |
| CN-112911934-A | Use of cyclodextrins as agrochemical delivery systems | 阿达玛马克西姆有限公司 | 2021-06-04 | — | — | CN | disclosed |
| EP-3790386-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | Adama Makhteshim Ltd. (IL) | 2021-03-17 | — | — | EP | disclosed |
| US-20210022335-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | ADAMA MAKHTESHIM LTD. (IL) | 2021-01-28 | — | — | US | disclosed |
| WO-2019215645-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | ADAMA MAKHTESHIM LTD. (IL) | 2019-11-14 | — | — | WO | disclosed |
| US-20120157310-A1 | Use of Alkyl Carboxylic Acid Amides as Penetration Enhancers | BAYER CORPSCIENCE AG (DE) | 2012-06-21 | — | — | US | disclosed |
| US-8124564-B2 | Use of alkyl carboxylic acid amides as penetration enhancers | BAYER CROPSCIENCE AG (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20070293514-A1 | Triazolopyrimidines | BAYER CROPSCIEMCE AG (DE) | 2007-12-20 | — | — | US | disclosed |
| US-20070293550-A1 | Use of Alkyl Carboxylic Acid Amides as Penetration Enhancers | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-12-20 | — | — | US | disclosed |
| US-20070259893-A1 | microbicides, fungicides; 7-amino-pyrazolo(1,5-a)pyrimidines; controlling unwanted microorganisms | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-11-08 | — | — | US | disclosed |
| US-20070244111-A1 | Pyrazolopyrimidines | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-10-18 | — | — | US | disclosed |
| US-20070197540-A1 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2007-08-23 | — | — | US | disclosed |
| US-20070185138-A1 | Imidazolopyrimidines used as fungicidal active ingredients | GEBAUER OLAF | 2007-08-09 | — | — | US | disclosed |
| EP-0927143-B1 | GLASS ARTICLE HAVING SURFACE COATING AND METHOD FOR PRODUCING THE SAME | NIPPON ELECTRIC GLASS CO (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-6280849-B1 | Glass article having surface coating of boric acid and method for producing the same | NIPPON ELECTRIC GLASS CO. LTD. (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0927143-A1 | GLASS ARTICLE HAVING SURFACE COATING OF BORIC ACID AND METHOD FOR PRODUCING THE SAME | NIPPON ELECTRIC GLASS CO., LTD (JP) | 1999-07-07 | — | — | EP | disclosed |
| WO-1999003791-A1 | GLASS ARTICLE HAVING SURFACE COATING OF BORIC ACID AND METHOD FOR PRODUCING THE SAME | NIPPON ELECTRIC GLASS CO., LTD. (JP) | 1999-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157310-A1 | Use of Alkyl Carboxylic Acid Amides as Penetration Enhancers | HCAR3, CNR1, HCAR2 | CA4 631/4885FAHD1 3521/4885CA1 862/4885 |
| US-20070197540-A1 | Pyrazolopyrimidines | QDPR, Q6ZSR9, RPLP2 | CA4 3750/4885FAHD1 2555/4885CA1 4735/4885 |
| US-20210022335-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | GYS2, DDT, PTPRG | CA4 120/4885FAHD1 1522/4885CA1 445/4885 |
| US-12127559-B2 | Use of cyclodextrins as agrochemical delivery system | DDT, GYS2, ACHE | CA4 116/4885FAHD1 1657/4885CA1 686/4885 |
| US-20070244111-A1 | Pyrazolopyrimidines | Q6ZSR9, RPLP2, DPYD | CA4 3443/4885FAHD1 1770/4885CA1 4628/4885 |
| US-20070293514-A1 | Triazolopyrimidines | QDPR, DPYD, Q6ZSR9 | CA4 2214/4885FAHD1 2221/4885CA1 4596/4885 |
| US-20070293550-A1 | Use of Alkyl Carboxylic Acid Amides as Penetration Enhancers | HCAR3, NCOA3, HCAR2 | CA4 929/4885FAHD1 3375/4885CA1 1470/4885 |
| US-20210386067-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | DDT, GYS2, ACHE | CA4 116/4885FAHD1 1657/4885CA1 686/4885 |
| US-20070259893-A1 | microbicides, fungicides; 7-amino-pyrazolo(1,5-a)pyrimidines; controlling unwanted microorganisms | PNPO, CYP4X1, CYP1B1 | CA4 2456/4885FAHD1 651/4885CA1 3930/4885 |
| US-20250057161-A1 | USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM | DDT, GYS2, ACHE | CA4 116/4885FAHD1 1657/4885CA1 686/4885 |
| US-20070185138-A1 | Imidazolopyrimidines used as fungicidal active ingredients | CYP4X1, PIK3C3, P2RX5 | CA4 2471/4885FAHD1 2356/4885CA1 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.