Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mafenide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 16/20 | 0.77 |
| ▸ | CA1 | P00915 | 13/20 | 0.77 |
| ▸ | CA9 | Q16790 | 9/20 | 0.77 |
| ▸ | CA14 | Q9ULX7 | 9/20 | 0.77 |
| ▸ | CA7 | P43166 | 9/20 | 0.77 |
| ▸ | CA12 | O43570 | 8/20 | 0.77 |
| ▸ | CA5A | P35218 | 8/20 | 0.77 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.77 |
| ▸ | CA6 | P23280 | 7/20 | 0.77 |
| ▸ | CA4 | P22748 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mafenide SCHEMBL26127074 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL6648930 | 0.93 | KDM4E (0.87) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL27599824 | 0.90 | KDM4E (0.82) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL10508044 | 0.89 | SMN1; SMN2 (0.80) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL41628 | 0.88 | CA2 (1.00) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL9295695 | 0.88 | CA2 (1.00) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL1072130 | 0.86 | CA2 (0.87) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL425524 | 0.86 | CA2 (1.00) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL1203324 | 0.86 | CA2 (1.00) | SMN1; SMN2KDM4ECA2CA1CA9 | |
| Mafenide SCHEMBL686407 | 0.84 | CA2 (0.95) | SMN1; SMN2KDM4ECA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2277 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260000678-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH PSEUDO-ALLERGIC REACTION | TAKASAKI UNIV OF HEALTH AND WELFARE (JP) | 2026-01-01 | — | — | US | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| EP-4501357-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR SUPPRESSING OR TREATING SYMPTOMS ACCOMPANYING PSEUDO-ALLERGIC REACTIONS | Takasaki University of Health and Welfare (JP) | 2025-02-05 | — | — | EP | claimed |
| WO-2025014745-A2 | COMPOSITE HYDROGEL WOUND DRESSINGS AND METHODS OF USE THEREOF | SAINT JOSEPH'S UNIVERSITY (US) | 2025-01-16 | — | — | WO | claimed |
| US-20240398852-A1 | NEGATIVELY CHARGED PARTICLES FOR THE TREATMENT OF INFLAMMATION-RELATED BURN INJURIES | ONCOUR PHARMA, INC. | 2024-12-05 | — | — | US | claimed |
| US-20240358766-A1 | ALLOGENEIC CULTURED KERATINOCYTE PRODUCTS | GOLDMAN SACHS BANK USA, AS ADMINISTRATIVE AGENT | 2024-10-31 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-4408400-A1 | NEGATIVELY CHARGED PARTICLES FOR THE TREATMENT OF INFLAMMATION-RELATED BURN INJURIES | Oncour Pharma, Inc. (US) | 2024-08-07 | — | — | EP | claimed |
| US-12036335-B2 | Adhesive containing microparticles | AVERY DENNISON CORPORATION (US) | 2024-07-16 | — | — | US | claimed |
| EP-3968906-B1 | IMPROVED SKIN SUBSTITUTE ADHERENCE, STRETCHABILITY, AND COMPLIANCE FOR SKIN SUBSTITUTES | WOODROOF E AUBREY (US) | 2024-07-10 | — | — | EP | claimed |
| EP-0168626-B1 | COMPOSITION FOR THE MANUFACTURE OF A MEDICAMENT FOR THE THERAPEUTIC TREATMENT OF TRAUMA OF THE SKIN | BAR-ILAN UNIVERSITY (IL) | 1990-09-12 | — | — | EP | claimed |
| WO-1990000903-A1 | METHOD AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF SEPTIC SHOCK | GENENTECH, INC. (US) | 1990-02-08 | — | — | WO | claimed |
| US-4777171-A | THIORIDAZINE | BAR-ILAN UNIVERSITY (IL) | 1988-10-11 | — | — | US | claimed |
| US-4725271-A | POLYMER, SOLVENT, HYDROGEN BONDING PLASTICIZER; PREFORMED OR CURED IN SITU; TIMED RELEASE | ENQUAY PHARMACEUTICAL ASSOCIATES (US) | 1988-02-16 | — | — | US | claimed |
| US-4654323-A | BLOCKING AGENT FOR CALCIUM CALMODULIN COMPLEX | BAR ILAN UNIVERSITY (IL) | 1987-03-31 | — | — | US | claimed |
| EP-0168626-A1 | Composition for the manufacture of a medicament for the therapeutic treatment of trauma of the skin | BAR-ILAN UNIVERSITY (IL) | 1986-01-22 | — | — | EP | claimed |
| US-4563184-A | POLYHYDROXYETHYL METHACRYLATE, POLYOXYETHYLENE GLYCOL, PLASTICIZER | ENQUAY, INC. | 1986-01-07 | — | — | US | claimed |
| EP-0138740-A2 | Synthetic resin wound dressing and method of manufacturing | ENQUAY PHARMACEUTICAL ASSOCIATES (US) | 1985-04-24 | — | — | EP | claimed |
| US-4393048-A | ALGINATE, GLYCERINE, WATER | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1983-07-12 | — | — | US | claimed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | claimed |