Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mafenide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 1.00 |
| ▸ | CA1 | P00915 | 13/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CA12 | O43570 | 10/20 | 0.95 |
| ▸ | CA9 | Q16790 | 10/20 | 0.95 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.95 |
| ▸ | CA4 | P22748 | 5/20 | 0.95 |
| ▸ | CA6 | P23280 | 5/20 | 0.95 |
| ▸ | CA5A | P35218 | 5/20 | 0.95 |
| ▸ | CA7 | P43166 | 5/20 | 0.95 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mafenide SCHEMBL1203324 | 1.00 | CA2 (1.00) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL686407 | 0.98 | CA2 (0.95) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL9295695 | 0.98 | CA2 (1.00) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL41628 | 0.98 | CA2 (1.00) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL2934434 | 0.93 | CA2 (0.91) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL1072130 | 0.91 | CA2 (0.87) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL27294054 | 0.91 | CA2 (0.87) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL11664949 | 0.89 | CA2 (0.83) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL27599824 | 0.87 | KDM4E (0.82) | CA2CA1MAPTCA12CA9 | |
| Mafenide SCHEMBL41627 | 0.86 | SMN1; SMN2 (1.00) | CA2CA1MAPTCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 473 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| WO-2025133679-A1 | COMPOUNDS AND COMPOSITION FOR DNA PROTECTION | ASSOCIAÇÃO PARA DESENVOLVIMENTO DO CENTRO ACADÉMICO DE INVESTIGAÇÃO E FORMAÇÃO BIOMÉDICA DO ALGARVE, AD-ABC (PT) | 2025-06-26 | — | — | WO | claimed |
| CN-116284022-B | Self-blinking fluorescent dye, synthesis and application thereof | 中国科学院大连化学物理研究所 | 2024-09-24 | — | — | CN | claimed |
| CN-118165544-A | Pentamethine cyanine dye fluorescent probe synthesis and application suitable for dynamic super-resolution imaging of cell membranes | 中国科学院大连化学物理研究所 | 2024-06-11 | — | — | CN | claimed |
| CN-116284022-A | Self-blinking fluorescent dye, synthesis and application thereof | 中国科学院大连化学物理研究所 | 2023-06-23 | — | — | CN | claimed |
| US-20230013402-A1 | REGENERATING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-01-19 | — | — | US | claimed |
| EP-4025302-A1 | REGENERATING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-07-13 | — | — | EP | claimed |
| CN-111333575-B | High-brightness carbonic anhydrase fluorescence lifetime imaging probe and synthesis and application thereof | 中国科学院大连化学物理研究所 | 2022-06-03 | — | — | CN | claimed |
| CN-111333574-B | Carbonic anhydrase detection fluorescent probe with high brightness and high light stability | 中国科学院大连化学物理研究所 | 2022-06-03 | — | — | CN | claimed |
| CN-111334080-B | Carbonic anhydrase fluorescent probe with high brightness and high light stability | 中国科学院大连化学物理研究所 | 2021-11-09 | — | — | CN | claimed |
| CN-111333574-A | Carbonic anhydrase detection fluorescent probe with high brightness and high light stability | 中国科学院大连化学物理研究所 | 2020-06-26 | — | — | CN | claimed |
| CN-110205010-A | A kind of preparation method of hydridization piezo-electric damping coating | 严勇 | 2019-09-06 | — | — | CN | claimed |
| CN-106867514-B | A kind of small-molecule fluorescent probe and its synthetic method and application for ratio identification people's carbonic anhydrase | 中国科学院大连化学物理研究所 | 2019-01-22 | — | — | CN | claimed |
| CN-106867514-A | A kind of small-molecule fluorescent probe and its synthetic method and application for ratio identification people's carbonic anhydrase | 中国科学院大连化学物理研究所 | 2017-06-20 | — | — | CN | claimed |
| US-20100221245-A1 | TOPICAL SKIN CARE COMPOSITION | DERMADOCTOR, LLC | 2010-09-02 | — | — | US | claimed |
| EP-1951262-A2 | METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION | The Board of Trustees of the University of Alabama (US) | 2008-08-06 | — | — | EP | claimed |
| US-20070203079-A1 | Methods of using small molecule compounds for neuroprotection | ALABAMA, UNIVERSITY OF | 2007-08-30 | — | — | US | claimed |
| WO-2007062186-A2 | METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA (US) | 2007-05-31 | — | — | WO | claimed |
| US-7109377-B2 | Synthesis of combinatorial libraries of compounds reminiscent of natural products | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-09-19 | — | — | US | claimed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230013402-A1 | REGENERATING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION | PER2, NCBP2, NOTCH1 | CA2 2696/4885CA1 3232/4885MAPT 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.