Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mafenide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 1.00 |
| ▸ | CA1 | P00915 | 11/20 | 1.00 |
| ▸ | CA12 | O43570 | 10/20 | 1.00 |
| ▸ | CA9 | Q16790 | 10/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 1.00 |
| ▸ | CA4 | P22748 | 5/20 | 1.00 |
| ▸ | CA6 | P23280 | 5/20 | 1.00 |
| ▸ | CA5A | P35218 | 5/20 | 1.00 |
| ▸ | CA7 | P43166 | 5/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mafenide SCHEMBL9295695 | 1.00 | CA2 (1.00) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL1203324 | 0.98 | CA2 (1.00) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL425524 | 0.98 | CA2 (1.00) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL686407 | 0.95 | CA2 (0.95) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL2934434 | 0.95 | CA2 (0.91) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL27294054 | 0.93 | CA2 (0.87) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL1072130 | 0.93 | CA2 (0.87) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL11664949 | 0.91 | CA2 (0.83) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL27599824 | 0.89 | KDM4E (0.82) | CA2CA1CA12CA9CA14 | |
| Mafenide SCHEMBL41627 | 0.88 | SMN1; SMN2 (1.00) | CA2CA1CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15960 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-20260090584-A1 | SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION | SCIENTIFIC HORIZONS CONSULTING LLC (US) | 2026-04-02 | — | — | US | claimed |
| US-20260091119-A1 | ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA | CELLIS AG (CH) | 2026-04-02 | — | — | US | claimed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | claimed |
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| US-20260027255-A1 | Cross-Linked Telechelic Polymer Compositions, Methods of Preparation Thereof, and Methods of Using Same | BETTY YU SKIN TECH ADVISORS LLC (US) | 2026-01-29 | — | — | US | claimed |
| US-20260000678-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH PSEUDO-ALLERGIC REACTION | TAKASAKI UNIV OF HEALTH AND WELFARE (JP) | 2026-01-01 | — | — | US | claimed |
| US-12465623-B2 | Use of parasites and extracellular vesicles obtained from parasites in cancer treatment | YEDITEPE UNIVERSITESI (TR) | 2025-11-11 | — | — | US | claimed |
| US-20250339551-A1 | AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES | HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) | 2025-11-06 | — | — | US | claimed |
| EP-4642484-A1 | TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE | Hangzhou Seehe Biotechnology Co., Ltd (CN) | 2025-11-05 | — | — | EP | claimed |
| US-4454128-A | ANTIBIOTICS | DR. KARL THOMAE GMBH (DE) | 1984-06-12 | — | — | US | claimed |
| US-4447422-A | Penicillins and compositions containing them | BEECHAM GROUP P.1.C. (GB) | 1984-05-08 | — | — | US | claimed |
| EP-0035161-B1 | CEPHALOSPORINS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1983-11-23 | — | — | EP | claimed |
| US-4393048-A | ALGINATE, GLYCERINE, WATER | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1983-07-12 | — | — | US | claimed |
| US-4370327-A | Cephalosporins and pharmaceutical compositions | BOEHRINGER INGELHEIM GMBH (DE) | 1983-01-25 | — | — | US | claimed |
| EP-0067610-A1 | Penicillins, a process for their preparation and compositions containing them | BEECHAM GROUP PLC (GB) | 1982-12-22 | — | — | EP | claimed |
| US-4169763-A | OF A CORYNEBACTERIA RESISTANT TO ASPARTIC ACID ANALOGS AND SULFA DRUGS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1979-10-02 | — | — | US | claimed |
| US-4156737-A | P-Aminomethyl-benzene-sulfonamide derivatives, process for their preparation and applications thereof | SEUREF A.G. (LI) | 1979-05-29 | — | — | US | claimed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
| US-3983209-A | HYDROPHOBIC BIOERODIBLE POLYMER, MICROBIOCIDE OR PROTEOLYTIC ENZYME | ALZA CORPORATION (US) | 1976-09-28 | — | — | US | claimed |