SCHEMBL4164940

SCHEMBL4164940

CC(=O)NC[C@H]1CN(c2ccc(-c3ccc(N4CCS(=O)(=O)CC4)nc3)cc2)C(=O)O1

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAOA P21397 5/20 0.49
ABCB11 O95342 1/20 0.49
MAOB P27338 2/20 0.48
LMNA P02545 1/20 0.48
PTGS1 P23219 1/20 0.48
CALML3 P27482 1/20 0.48
SDHA P31040 1/20 0.48
F10 P00742 9/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4164949 1.00 MAOA (0.49) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL13945030 0.93 ABCB11 (0.49) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL4179294 0.92 ABCB11 (0.47) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL4179291 0.92 ABCB11 (0.47) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL4165374 0.92 MAOA (0.49) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL4165377 0.92 MAOA (0.49) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL4173660 0.89 MAOA (0.63) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL4173652 0.89 MAOA (0.63) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL4177057 0.88 MAOA (0.61) MAOAABCB11MAOBLMNAPTGS1
SCHEMBL4177056 0.88 MAOA (0.61) MAOAABCB11MAOBLMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US claimed
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation SINDKHEDKAR MILIND D 2009-01-15 US disclosed
EP-1912980-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION Wockhardt Limited (IN) 2008-04-23 EP disclosed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO disclosed
WO-2007023507-A2 OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION WOCKHARDT LIMITED (IN) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090018123-A1 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation POLL, POLM, POLRMT MAOA 3788/4885ABCB11 2781/4885MAOB 3240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.