SCHEMBL4166115

SCHEMBL4166115

Oc1nc2nccnc2c(O)c1-c1c(F)cc(F)cc1F

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.31
ADORA2A P29274 1/20 0.31
ERN1 O75460 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13907013 0.76 KDM4E (0.42)
SCHEMBL4148411 0.75 ADORA2A (0.32) ADORA2A
SCHEMBL4151460 0.72 PRKD3 (0.33) ADORA2A
SCHEMBL5752259 0.72 IDO1 (0.32)
SCHEMBL4020403 0.70 CA9 (0.35) NOTUMERN1
SCHEMBL13907015 0.68 KMT2A (0.41)
SCHEMBL940501 0.68 GRIN2D (0.35)
SCHEMBL29184379 0.67 KMT2A (0.39) ERN1
SCHEMBL14086458 0.67 PRKD3 (0.30)
SCHEMBL13906856 0.67 PRKD3 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090069333-A1 FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2009-03-12 US disclosed
US-20090069333-A1 FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2009-03-12 US disclosed
US-20090069333-A1 FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2009-03-12 US disclosed
US-7410967-B2 Pyridodiazines as plant fungicides SYNGENTA CROP PROTECTION, INC. (US) 2008-08-12 US disclosed
US-7410967-B2 Pyridodiazines as plant fungicides SYNGENTA CROP PROTECTION, INC. (US) 2008-08-12 US disclosed
US-7410967-B2 Pyridodiazines as plant fungicides SYNGENTA CROP PROTECTION, INC. (US) 2008-08-12 US disclosed
EP-1575948-B1 PYRIDODIAZINES AS PLANT FUNGICIDES SYNGENTA LTD (GB) 2007-02-14 EP disclosed
US-20060205717-A1 Pyridodiazines as plant fungicides SYNGENTA CROP PROTECTION, INC. 2006-09-14 US disclosed
EP-1575948-A1 PYRIDODIAZINES AS PLANT FUNGICIDES Syngenta Limited (GB) 2005-09-21 EP disclosed
WO-2004056825-A1 PYRIDODIAZINES AS PLANT FUNGICIDES SYNGENTA LIMITED (GB) 2004-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069333-A1 FUNGICIDES CYP4Z1, CYP4X1, PRXL2A NOTUM 2882/4885ADORA2A 1641/4885ERN1 2021/4885
US-20060205717-A1 Pyridodiazines as plant fungicides CYP4Z1, CYP4X1, PNPO NOTUM 1779/4885ADORA2A 899/4885ERN1 2620/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.