SCHEMBL4166158

SCHEMBL4166158

O=c1ccn([C@@H]2O[C@H](COP(=O)(O)O)C(O)C2O)c(=O)[nH]1

nearest known ligand 0.83

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 8/20 0.83
P2RY2 P41231 12/20 0.81
P2RY4 P51582 6/20 0.81
P2RY14 Q15391 7/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30679287 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL2683846 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL285071 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL157645 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL4071893 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL157644 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL2056922 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL2056709 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL2056916 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14
SCHEMBL317204 1.00 P2RY6 (0.83) P2RY6P2RY2P2RY4P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11767546-B2 Enzymatic method for preparation of UDP-GlcNAc MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2023-09-26 US disclosed
EP-3874055-B1 ENZYMATIC METHOD FOR PREPARATION OF UDP-GALACTOSE MAX PLANCK GESELLSCHAFT (DE) 2023-06-14 EP disclosed
EP-3874056-B1 ENZYMATIC METHOD FOR PREPARATION OF UDP-GLCNAC MAX PLANCK GESELLSCHAFT (DE) 2023-06-14 EP disclosed
US-20220389480-A1 SEPARATION OF NUCLEIC ACID COMPONENT COMPOUNDS ON ZWITTERIONIC STATIONARY PHASES WATERS TECHNOLOGIES CORPORATION (US) 2022-12-08 US disclosed
US-20220220135-A1 HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES BAR-ILAN UNIVERSITY (IL) 2022-07-14 US disclosed
EP-3819382-A1 ENZYMATIC METHOD FOR PREPARATION OF UDP-GLCNAC Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2021-05-12 EP disclosed
EP-3819381-A1 ENZYMATIC METHOD FOR PREPARATION OF UDP-GALACTOSE Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2021-05-12 EP disclosed
WO-2021015622-A1 SYNTHESIS OF 6-AZIDO-6-DEOXY-2-N-ACETYL-HEXOSAMINE-NUCLEOSIDE DIPHOSPHATE SYNAFFIX B.V. (NL) 2021-01-28 WO disclosed
US-20200216871-A1 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS INVITROGEN CORPORATION 2020-07-09 US disclosed
US-20170362624-A1 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS Life Technologies Corporation 2017-12-21 US disclosed
US-9645140-B2 Labeling and detection of post translationally modified proteins Life Technologies Corporation (US) 2017-05-09 US disclosed
US-20170112948-A1 Inorganic-organic hybrid compound Karlsruher Institut für Technologie (DE) 2017-04-27 US disclosed
US-20120219963-A1 DERIVATIVES OF URIDINE PHOSPHATE AND THEIR USES IN PROTEIN BINDING ASSAYS KING'S COLLEGE LONDON OF STRAND (GB) 2012-08-30 US disclosed
US-20120116067-A1 METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES UNIVERSITAET HAMBURG (DE) 2012-05-10 US disclosed
US-20110137023-A1 METHOD FOR PRODUCING PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES UNIVERSITAET HAMBURG (DE) 2011-06-09 US disclosed
US-7939510-B2 Di(uridine 5′-)tetraphosphate and salts thereof INSPIRE PHARMACEUTICALS, INC. (US) 2011-05-10 US disclosed
WO-2010015245-A1 METHOD FOR PRODUCING PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES UNIVERSITÄT HAMBURG (DE) 2010-02-11 WO disclosed
US-20090326050-A1 DI(URIDINE 5'-)TETRAPHOSPHATE AND SALTS THEREOF MERCK SHARP & DOHME CORP. 2009-12-31 US disclosed
US-7528119-B2 Di(uridine 5′-)tetraphosphate and salts thereof INSPIRE PHARMACEUTICALS, INC. (US) 2009-05-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110137023-A1 METHOD FOR PRODUCING PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES TYMP, PNP, NUDT1 P2RY6 247/4885P2RY2 489/4885P2RY4 272/4885
US-20220220135-A1 HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES UPP1, NUDT14, UMPS P2RY6 1256/4885P2RY2 1300/4885P2RY4 1075/4885
US-20090326050-A1 DI(URIDINE 5'-)TETRAPHOSPHATE AND SALTS THEREOF UMPS, NUDT1, UPP1 P2RY6 56/4885P2RY2 222/4885P2RY4 83/4885
US-20120116067-A1 METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES PNP, TYMP, DPYD P2RY6 720/4885P2RY2 1020/4885P2RY4 539/4885
US-20200216871-A1 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS PTMS, DNPEP, BTD P2RY6 3600/4885P2RY2 4442/4885P2RY4 4456/4885
US-20170112948-A1 Inorganic-organic hybrid compound SLCO4C1, SLCO2A1, SLCO1A2 P2RY6 802/4885P2RY2 1037/4885P2RY4 518/4885
US-20120219963-A1 DERIVATIVES OF URIDINE PHOSPHATE AND THEIR USES IN PROTEIN BINDING ASSAYS OGA, OSTC, UPP1 P2RY6 937/4885P2RY2 1356/4885P2RY4 618/4885
US-20170362624-A1 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS PTMS, DNPEP, BTD P2RY6 3600/4885P2RY2 4442/4885P2RY4 4456/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.