Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858319 | 0.86 | ALDH1A1 (0.36) | KDM4EALDH1A1HPGD | |
| SCHEMBL2859496 | 0.84 | KDM4E (0.35) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2854655 | 0.83 | FLT3 (0.42) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2862382 | 0.83 | KDM4E (0.34) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2863087 | 0.81 | KDM4E (0.38) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2866494 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1MAPT | |
| SCHEMBL2862394 | 0.80 | KDM4E (0.34) | KDM4EMAPT | |
| SCHEMBL2860006 | 0.77 | CES2 (0.32) | ALDH1A1 | |
| SCHEMBL2863217 | 0.76 | FLT3 (0.42) | KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2857137 | 0.73 | LMNA (0.31) | KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247522-A1 | Hsp90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-10-01 | — | — | US | disclosed |
| US-7538224-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032532-A1 | Hsp90 family protein inhibitors | HSP90AB1, HSP90B1, HSP90AB2P | KDM4E 2968/4885ALDH1A1 2940/4885MAPT 1791/4885 |
| US-20090247522-A1 | Hsp90 FAMILY PROTEIN INHIBITORS | HSP90AB1, HSP90B1, HSP90AB2P | KDM4E 2968/4885ALDH1A1 2940/4885MAPT 1791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.